CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006069
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
 AAA52576.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54859.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54858.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; CAB54857.1; BAG36030.1; AAH37549.1; AAH42421.1; AAH71595.1; CAA48346.1; CAA49512.1 
Protein Name
 Glycerol kinase 
Protein Synonyms/Alias
 GK; Glycerokinase; ATP:glycerol 3-phosphotransferase 
Gene Name
 GK 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
6**MAASKKAVLGPLVubiquitination[1]
86NIDISNIKAIGVSNQubiquitination[1]
128STVESLSKRIPGNNNubiquitination[1]
347KTSEEIEKLAKEVGTubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Key enzyme in the regulation of glycerol uptake and metabolism. 
Sequence Annotation
 NP_BIND 433 437 ATP (By similarity).
 BINDING 20 20 Substrate (By similarity).
 BINDING 24 24 ATP (By similarity).
 BINDING 94 94 Substrate (By similarity).
 BINDING 148 148 Substrate (By similarity).
 BINDING 265 265 Substrate (By similarity).
 BINDING 287 287 ATP (By similarity).
 BINDING 332 332 ATP; via carbonyl oxygen (By similarity).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Disease mutation; Glycerol metabolism; Kinase; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Polymorphism; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 559 AA 
Protein Sequence
MAASKKAVLG PLVGAVDQGT SSTRFLVFNS KTAELLSHHQ VEIKQEFPRE GWVEQDPKEI 60
LHSVYECIEK TCEKLGQLNI DISNIKAIGV SNQRETTVVW DKITGEPLYN AVVWLDLRTQ 120
STVESLSKRI PGNNNFVKSK TGLPLSTYFS AVKLRWLLDN VRKVQKAVEE KRALFGTIDS 180
WLIWSLTGGV NGGVHCTDVT NASRTMLFNI HSLEWDKQLC EFFGIPMEIL PNVRSSSEIY 240
GLMKAGALEG VPISGCLGDQ SAALVGQMCF QIGQAKNTYG TGCFLLCNTG HKCVFSDHGL 300
LTTVAYKLGR DKPVYYALEG SVAIAGAVIR WLRDNLGIIK TSEEIEKLAK EVGTSYGCYF 360
VPAFSGLYAP YWEPSARGII CGLTQFTNKC HIAFAALEAV CFQTREILDA MNRDCGIPLS 420
HLQVDGGMTS NKILMQLQAD ILYIPVVKPS MPETTALGAA MAAGAAEGVG VWSLEPEDLS 480
AVTMERFEPQ INAEESEIRY STWKKAVMKS MGWVTTQSPE SGIP 524 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005741; C:mitochondrial outer membrane; NAS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004370; F:glycerol kinase activity; NAS:UniProtKB.
 GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
 GO:0006071; P:glycerol metabolic process; NAS:UniProtKB.
 GO:0046167; P:glycerol-3-phosphate biosynthetic process; IMP:BHF-UCL.
 GO:0019432; P:triglyceride biosynthetic process; TAS:Reactome. 
Interpro
 IPR018485; Carb_kinase_FGGY_C.
 IPR018483; Carb_kinase_FGGY_CS.
 IPR018484; Carb_kinase_FGGY_N.
 IPR005999; Glycerol_kin. 
Pfam
 PF02782; FGGY_C
 PF00370; FGGY_N 
SMART
  
PROSITE
 PS00933; FGGY_KINASES_1
 PS00445; FGGY_KINASES_2 
PRINTS