CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000593
UniProt Accession
Genbank Protein ID
 D83262 
Genbank Nucleotide ID
Protein Name
 Excitatory amino acid transporter 4 
Protein Synonyms/Alias
 High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 
Gene Name
 Slc1a6 
Gene Synonyms/Alias
 Eaat4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
538LTLPSLGKPYKSLMAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium (By similarity). 
Sequence Annotation
 CARBOHYD 213 213 N-linked (GlcNAc...) (Potential).
 CARBOHYD 229 229 N-linked (GlcNAc...) (Potential).
 CARBOHYD 236 236 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Membrane; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 561 AA 
Protein Sequence
MSSHGNSLFL RESGAGGGCL QGLQDSLQQR ALRTRLRLQT MTREHVRRFL RRNAFILLTV 60
SAVIIGVSLA FALRPYQLSY RQIKYFSFPG ELLMRMLQML VLPLIVSSLV TGMASLDNKA 120
TGRMGMRAAV YYMVTTVIAV FIGILMVTII HPGKGSKEGL HREGRIETVP TADAFMDLVR 180
NMFPPNLVEA CFKQFKTQYS TRVVTRTIVR TDNGSELGAS MSPTSSVENE TSILENVTRA 240
LGTLQEVISF EETVPVPGSA NGINALGLVV FSVAFGLVIG GMKHKGRVLR DFFDSLNEAI 300
MRLVGIIIWY APVGILFLIA GKILEMEDMA VLGGQLGMYT LTVIVGLFLH AGGVLPLIYF 360
LVTHRNPFPF IGGMLQALIT AMGTSSSSAT LPITFRCLEE GLGVDRRITR FVLPVGATVN 420
MDGTALYEAL AAIFIAQVNN YELNLGQITT ISITATAASV GAAGIPQAGL VTMVIVLTSV 480
GLPTEDITLI IAVDWFLDRL RTMTNVLGDS IGAAVIEHLS QRELELQEAE LTLPSLGKPY 540
KSLMAQEKGA SRGRGGNESV M 561 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005313; F:L-glutamate transmembrane transporter activity; IMP:MGI.
 GO:0017153; F:sodium:dicarboxylate symporter activity; IEA:InterPro.
 GO:0042391; P:regulation of membrane potential; IMP:MGI. 
Interpro
 IPR001991; Na-dicarboxylate_symporter.
 IPR018107; Na-dicarboxylate_symporter_CS. 
Pfam
 PF00375; SDF 
SMART
  
PROSITE
 PS00713; NA_DICARBOXYL_SYMP_1
 PS00714; NA_DICARBOXYL_SYMP_2 
PRINTS
 PR00173; EDTRNSPORT.