CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041251
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transferrin receptor (P90, CD71), isoform CRA_c 
Protein Synonyms/Alias
 Transferrin receptor protein 1, serum form 
Gene Name
 TFRC 
Gene Synonyms/Alias
 hCG_22086 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
47RLYWDDLKRKLSEKLubiquitination[1, 2]
49YWDDLKRKLSEKLDSubiquitination[2]
53LKRKLSEKLDSTDFTubiquitination[1, 2]
64TDFTGTIKLLNENSYubiquitination[1, 2, 3, 4]
80PREAGSQKDENLALYubiquitination[1, 2, 3]
108WRDQHFVKIQVKDSAubiquitination[1]
112HFVKIQVKDSAQNSVubiquitination[2]
124NSVIIVDKNGRLVYLubiquitination[1, 2, 3]
143GGYVAYSKAATVTGKubiquitination[1, 2, 3, 4]
150KAATVTGKLVHANFGubiquitination[2]
159VHANFGTKKDFEDLYubiquitination[1]
160HANFGTKKDFEDLYTubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Receptor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 679 AA 
Protein Sequence
MIGYLGYCKG VEPKTECERL AGTESPVREE PGEDFPAARR LYWDDLKRKL SEKLDSTDFT 60
GTIKLLNENS YVPREAGSQK DENLALYVEN QFREFKLSKV WRDQHFVKIQ VKDSAQNSVI 120
IVDKNGRLVY LVENPGGYVA YSKAATVTGK LVHANFGTKK DFEDLYTPVN GSIVIVRAGK 180
ITFAEKVANA ESLNAIGVLI YMDQTKFPIV NAELSFFGHA HLGTGDPYTP GFPSFNHTQF 240
PPSRSSGLPN IPVQTISRAA AEKLFGNMEG DCPSDWKTDS TCRMVTSESK NVKLTVSNVL 300
KEIKILNIFG VIKGFVEPDH YVVVGAQRDA WGPGAAKSGV GTALLLKLAQ MFSDMVLKDG 360
FQPSRSIIFA SWSAGDFGSV GATEWLEGYL SSLHLKAFTY INLDKAVLGT SNFKVSASPL 420
LYTLIEKTMQ NVKHPVTGQF LYQDSNWASK VEKLTLDNAA FPFLAYSGIP AVSFCFCEDT 480
DYPYLGTTMD TYKELIERIP ELNKVARAAA EVAGQFVIKL THDVELNLDY ERYNSQLLSF 540
VRDLNQYRAD IKEMGLSLQW LYSARGDFFR ATSRLTTDFG NAEKTDRFVM KKLNDRVMRV 600
EYHFLSPYVS PKESPFRHVF WGSGSHTLPA LLENLKLRKQ NNGAFNETLF RNQLALATWT 660
IQGAANALSG DVWDIDNEF 679 
Gene Ontology
 GO:0005768; C:endosome; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0008233; F:peptidase activity; IEA:InterPro.
 GO:0006879; P:cellular iron ion homeostasis; IEA:Compara.
 GO:0030316; P:osteoclast differentiation; IEA:Compara.
 GO:0045780; P:positive regulation of bone resorption; IEA:Compara.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR007484; Peptidase_M28.
 IPR003137; Protease-assoc_domain.
 IPR007365; TFR-like_dimer_dom. 
Pfam
 PF02225; PA
 PF04389; Peptidase_M28
 PF04253; TFR_dimer 
SMART
  
PROSITE
  
PRINTS