CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011732
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein pop-1 
Protein Synonyms/Alias
 Posterior pharynx defect protein 1 
Gene Name
 pop-1 
Gene Synonyms/Alias
 W10C8.2 
Created Date
 July 27, 2013 
Organism
 Caenorhabditis elegans 
NCBI Taxa ID
 6239 
Lysine Modification
Position
Peptide
Type
References
185RRAQGGGKAKKDDHVacetylation[1]
187AQGGGKAKKDDHVKKacetylation[1]
188QGGGKAKKDDHVKKPacetylation[1]
Reference
 [1] Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1.
 Gay F, Calvo D, Lo MC, Ceron J, Maduro M, Lin R, Shi Y.
 Genes Dev. 2003 Mar 15;17(6):717-22. [PMID: 12651889] 
Functional Description
 Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. 
Sequence Annotation
 DNA_BIND 192 262 HMG box.
 REGION 88 130 Involved in nuclear asymmetry.
 MOD_RES 118 118 Phosphoserine; by LIT1.
 MOD_RES 127 127 Phosphoserine; by LIT1.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Developmental protein; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 438 AA 
Protein Sequence
MMADEELGDE VKVFRRDEDA DDDPMISGET SEQQLADDKK EAVMEAELDG AGRNPSIDVL 60
KSAFPKVEPM SPSFPGLMSH FSPGYSAAAL PMFMPLFMNP YAAALRSPSL MFPMGAMSPT 120
FPMFPPSPVY GAAIAAAAAK QHFENMAPLN MRAGHPMNQM GMPPYMHPSS MAPQNVDRRA 180
QGGGKAKKDD HVKKPLNAFM WFMKENRKAL LEEIGNNEKQ SAELNKELGK RWHDLSKEEQ 240
AKYFEMAKKD KETHKERYPE WSARENYAVN KKKTKKRRDK SIPSENNDQK KCRARFGVNN 300
TEMWCKFCKR KKKCEYATDR SGGSDITDSQ DGRGTSGAYS SSSESPSPKA NAGIALTTQQ 360
QQAAMMHTML MQMRLGSTTG ASTHVPSPLA SSSAGRSPLD ANASDSESDV EEEEDEQIDP 420
TVMQQTHDML MQESMCTI 438 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:WormBase.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:WormBase.
 GO:0008356; P:asymmetric cell division; IMP:UniProtKB.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IBA:RefGenome.
 GO:0009880; P:embryonic pattern specification; IMP:WormBase.
 GO:0007500; P:mesodermal cell fate determination; IMP:WormBase.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0043282; P:pharyngeal muscle development; IMP:WormBase.
 GO:0010085; P:polarity specification of proximal/distal axis; IGI:WormBase.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:WormBase.
 GO:0040026; P:positive regulation of vulval development; IMP:WormBase.
 GO:0009786; P:regulation of asymmetric cell division; IGI:WormBase.
 GO:0042659; P:regulation of cell fate specification; IGI:WormBase. 
Interpro
 IPR009071; HMG_box_dom.
 IPR024940; TCF/LEF. 
Pfam
 PF00505; HMG_box 
SMART
 SM00398; HMG 
PROSITE
 PS50118; HMG_BOX_2 
PRINTS