CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043669
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 WD repeat-containing protein 44 
Protein Synonyms/Alias
  
Gene Name
 WDR44 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
340GKSVKRAKHLAEEYGubiquitination[1, 2]
418MGAVWTMKFSHCGRLubiquitination[3]
656EPLPGENKILVTSNDubiquitination[1, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 806 AA 
Protein Sequence
XTDLSNIPGL LAIDQVLPEE SQKAESQNTF EETELELKKC FPSDETCEKP VDETTKLTQT 60
SSTEQLNVLE TETEVLNKEA VEVKGGGDVL EPVSSDSLST KDFAAVEEVA PAKPPRHLTP 120
EPDIVASTKK PVPARPPPPT NFPPPRPPPP SRPAPPPRKR KSELEFETLK TPDIDVPKEN 180
ITSDSLLTAS MASESTVKDS QPSLDLASAT SGDKIVTAQE NGKAPDGQTV AGEVMGPQRP 240
RSNSGRELTD EEILASVMIK NLDTGEEIPL SLAEEKLPTG INPLTLHIMR RTKEYVSNDA 300
AQSDDEEKLQ SQPTDTDGGR LKQKTTQLKK FLGKSVKRAK HLAEEYGERA INKVKSVRDE 360
VFHTDQDDPS SSDDEGMPYT RPVKFKAAHG FKGPYDFDQI KVVQDLSGEH MGAVWTMKFS 420
HCGRLLASAG QDNVVRIWAL KNAFDYFNNM RMKYNTEGRV SPSPSQESLS SSKSDTDTGV 480
CSGTDEDPDD KNAPFRQRPF CKYKGHTADL LDLSWSKNYF LLSSSMDKTV RLWHISRREC 540
LCCFQHIDFV TAIAFHPRDD RYFLSGSLDG KLRLWNIPDK KVALWNEVDG QTKLITAANF 600
CQNGKYAVIG TYDGRCIFYD TEHLKYHTQI HVRSTRGRNK VGRKITGIEP LPGENKILVT 660
SNDSRIRLYD LRDLSLSMKY KGYVNSSSQI KASFSHDFTY LVSGSEDKYV YIWSTYHDLS 720
KFTSVRRDRN DFWEGIKAHN AVVTSAIFAP NPSLMLSLDV QSEKSEGNEK SEDAEVLDAT 780
PSAMSSRYVA QAGLELLASK RYYEDR 806 
Gene Ontology
  
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.