CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022228
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TBCC domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 TBCCD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
35FSLHYLRKISTYVQIacetylation[1]
506QKIQIWQKTVKEAHLubiquitination[2]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration. 
Sequence Annotation
 DOMAIN 290 435 C-CAP/cofactor C-like.  
Keyword
 Complete proteome; Cytoplasm; Cytoskeleton; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 557 AA 
Protein Sequence
MDQSRVLLWV KAEPFIVGAL QVPPPSKFSL HYLRKISTYV QIRATEGAYP RLYWSTWRHI 60
ACGKLQLAKD LAWLYFEIFD SLSMKTPEER LEWSEVLSNC MSEEEVEKQR NQLSVDTLQF 120
LLFLYIQQLN KVSLRTSLIG EEWPSPRNKS QSPDLTEKSN CHNKNWNDYS HQAFVYDHLS 180
DLLELLLDPK QLTASFHSTH SSLVSREAVV ALSFLIEGTI SRARKIYPLH ELALWQPLHA 240
DSGFSKISKT FSFYKLETWL RSCLTGNPFG TSACLKSGKK LAWAHQVEGT TKRAKIACNT 300
HVAPRMHRLV VMSQVYKQTL AKSSDTLAGA HVKIHRCNES FIYLLSPLRS VTIEKCRNSI 360
FVLGPVGTTL HLHSCDNVKV IAVCHRLSIS STTGCIFHVL TPTRPLILSG NQTVTFAPFH 420
THYPMLEDHM ARTGLATVPN YWDNPMVVCR ENSDTRVFQL LPPCEFYVFI IPFEMEGDTT 480
EIPGGLPSVY QKALGQREQK IQIWQKTVKE AHLTKDQRKQ FQVLVENKFY EWLINTGHRQ 540
QLDSLVPPAA GSKQAAG 557 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0031616; C:spindle pole centrosome; IDA:UniProtKB.
 GO:0000902; P:cell morphogenesis; IEA:InterPro.
 GO:0051661; P:maintenance of centrosome location; IMP:UniProtKB.
 GO:0051684; P:maintenance of Golgi location; IMP:UniProtKB.
 GO:0030334; P:regulation of cell migration; IMP:UniProtKB.
 GO:0008360; P:regulation of cell shape; IMP:UniProtKB. 
Interpro
 IPR017901; C-CAP_CF_C-like.
 IPR016098; CAP/MinC_C.
 IPR006599; CARP_motif.
 IPR012945; Tubulin-bd_cofactor_C. 
Pfam
 PF07986; TBCC 
SMART
 SM00673; CARP 
PROSITE
 PS51329; C_CAP_COFACTOR_C 
PRINTS