UniProt Accession

 GATA_MOUSE; Q9CZN8; Q3TDF6; Q6NS53 

Genbank Protein ID

 AK012351; AK170225; BC070459 

Genbank Nucleotide ID

 BAB28181.1; BAE41646.1; AAH70459.1 

Protein Name

 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial 

Protein Synonyms/Alias

 Glu-AdT subunit A; Glutaminyl-tRNA synthase-like protein 1 

Gene Name

 Qrsl1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
57	KQAEESEKRYKQGQS	acetylation	[1, 2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity). 

Sequence Annotation

 ACT_SITE 76 76 Charge relay system (By similarity).
 ACT_SITE 168 168 Charge relay system (By similarity).
 ACT_SITE 192 192 Acyl-ester intermediate (By similarity).  

Keyword

 ATP-binding; Complete proteome; Ligase; Mitochondrion; Nucleotide-binding; Protein biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 525 AA 

Protein Sequence

Gene Ontology

 GO:0030956; C:glutamyl-tRNA(Gln) amidotransferase complex; IEA:HAMAP.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0050567; F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity; IEA:HAMAP.
 GO:0070681; P:glutaminyl-tRNAGln biosynthesis via transamidation; IEA:HAMAP.
 GO:0032543; P:mitochondrial translation; IEA:HAMAP. 

Interpro

 IPR000120; Amidase.
 IPR023631; Amidase_dom.
 IPR004412; GatA. 

Pfam

 PF01425; Amidase 

SMART

  

PROSITE

 PS00571; AMIDASES 

PRINTS