CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012939
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial inner membrane protein 
Protein Synonyms/Alias
 Mitofilin 
Gene Name
 Immt 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
77HFRESVEKTIPYSDKacetylation[1]
234RTVEGALKERRKAVDacetylation[1]
238GALKERRKAVDEAADacetylation[1]
249EAADALLKAKEELEKacetylation[1]
251ADALLKAKEELEKMKacetylation[1]
256KAKEELEKMKTIIEDacetylation[1]
258KEELEKMKTIIEDAKacetylation[1]
282YITAAEEKLHSMIVDacetylation[1]
295VDLDSVVKKVQAAQSacetylation[1]
305QAAQSEAKVVSQYHEacetylation[1]
375NRELAQQKATEKQHIacetylation[1]
403AFDSAVAKALEHHRSacetylation[1]
517VAEEEARKAHQLWLSacetylation[1]
592ARFYAVQKLAGRVAMacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 MOD_RES 174 174 N6-acetyllysine (By similarity).
 MOD_RES 403 403 N6-acetyllysine (By similarity).
 MOD_RES 458 458 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 609 AA 
Protein Sequence
MLRACQLSGV TVAAQSCLCG KFVLRPLRPC RRYSTSSSSG VTAGKIAGAG LLFVGGGIGG 60
TILYAKWDSH FRESVEKTIP YSDKLFGMVL GSAPYTVPLP KKPIQSGPLK ISSVSEVMTD 120
SELPMAQTQE TNGDTPASAA GDPAPEVEHE DTINTECPNT DEGTSTFVTA ALAKSLEDAL 180
NQTATVTRQT ITAQNAAVQA VKAHSSTLKT AMDNSEIAGE KKSAQWRTVE GALKERRKAV 240
DEAADALLKA KEELEKMKTI IEDAKKREIA GATPYITAAE EKLHSMIVDL DSVVKKVQAA 300
QSEAKVVSQY HELVVQARDD FRKELDSITP DITPGWKGMS ISDLAGTLST DDLNALIAHA 360
HRRIDQLNRE LAQQKATEKQ HIELALERQK LEEKRAFDSA VAKALEHHRS EIQAEQDRKV 420
EEVRDAMENE MRTQLRRQAA AHTDHLRDVL KVQEQELKFE FEQDLSEKLS EQELEFHRRS 480
QEQMDNFTLD INTAYARLRG IEQAVQSHAV AEEEARKAHQ LWLSVEALKY SMKTSSAEMP 540
TIPLGSAVEA IRVSCSDNEF TQALTAAIPP ESLTRGVYSE ETLRARFYAV QKLAGRVAMI 600
DETKNSLYQ 609 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0051560; P:mitochondrial calcium ion homeostasis; IEA:Compara.
 GO:0009409; P:response to cold; IEP:RGD. 
Interpro
 IPR019133; Mt-IM_prot_Mitofilin. 
Pfam
 PF09731; Mitofilin 
SMART
  
PROSITE
  
PRINTS