CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021853
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Selenocysteine lyase 
Protein Synonyms/Alias
 mSCL 
Gene Name
 Scly 
Gene Synonyms/Alias
 Scl 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
60YVSGRKAKDIINAARubiquitination[1]
77LAKMIGGKPQDIIFTubiquitination[1]
202SEISRRIKALNQIRAubiquitination[1]
328RLEAEFGKRIHLNSRacetylation[2]
328RLEAEFGKRIHLNSRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium. 
Sequence Annotation
 ACT_SITE 375 375 S-selanylcysteine intermediate (By
 MOD_RES 247 247 N6-(pyridoxal phosphate)lysine (By  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Lyase; Pyridoxal phosphate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 432 AA 
Protein Sequence
MDAARNGALG SVESLPDRKV YMDYNATTPL EPEVIQAVTE AMKEAWGNPS SSYVSGRKAK 60
DIINAARASL AKMIGGKPQD IIFTSGGTES NNLVIHSMVR CFHEQQTLKG NMVDQHSPEE 120
GTRPHFITCT VEHDSIRLPL EHLVENQMAE VTFVPVSKVN GQAEVEDILA AVRPTTCLVT 180
IMLANNETGV IMPVSEISRR IKALNQIRAA SGLPRVLVHT DAAQALGKRR VDVEDLGVDF 240
LTIVGHKFYG PRIGALYVRG VGKLTPLYPM LFGGGQERNF RPGTENTPMI AGLGKAADLV 300
SENCETYEAH MRDIRDYLEE RLEAEFGKRI HLNSRFPGVE RLPNTCNFSI QGSQLQGYTV 360
LAQCRTLLAS VGASCHSNHE DRPSPVLLSC GIPVDVARNA VRLSVGRGTT RADVDLIVQD 420
LKQAVAQLEG RL 432 
Gene Ontology
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0009000; F:selenocysteine lyase activity; IEA:EC.
 GO:0016740; F:transferase activity; IEA:UniProtKB-KW. 
Interpro
 IPR000192; Aminotrans_V/Cys_dSase.
 IPR016454; Cysteine_dSase_NifS.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00266; Aminotran_5 
SMART
  
PROSITE
 PS00595; AA_TRANSFER_CLASS_5 
PRINTS