UniProt Accession

 H2A_PLAFA; P40282 

Genbank Protein ID

 M86865 

Genbank Nucleotide ID

 AAA29612.1 

Protein Name

 Histone H2A 

Protein Synonyms/Alias

  

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Plasmodium falciparum 

NCBI Taxa ID

 5833 

Lysine Modification

Position	Peptide	Type	References
4	****MSAKGKTGRKK	acetylation	[1]
6	**MSAKGKTGRKKAS	acetylation	[1]

Reference

 [1] Global histone analysis by mass spectrometry reveals a high content of acetylated lysine residues in the malaria parasite Plasmodium falciparum.
 Trelle MB, Salcedo-Amaya AM, Cohen AM, Stunnenberg HG, Jensen ON.
 J Proteome Res. 2009 Jul;8(7):3439-50. [PMID: 19351122] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

  

Keyword

 Chromosome; DNA-binding; Nucleosome core; Nucleus. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 132 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR002119; Histone_H2A. 

Pfam

 PF00125; Histone 

SMART

 SM00414; H2A 

PROSITE

 PS00046; HISTONE_H2A 

PRINTS

 PR00620; HISTONEH2A.