UniProt Accession

 SNIP1_HUMAN; Q8TAD8; Q96SP9; Q9H9T7 

Genbank Protein ID

 AY081909; AK022615; AK027622; BC027040 

Genbank Nucleotide ID

 AAL91140.1; BAB14134.1; BAB55241.1; AAH27040.1 

Protein Name

 Smad nuclear-interacting protein 1 

Protein Synonyms/Alias

 FHA domain-containing protein SNIP1 

Gene Name

 SNIP1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
30	LPAGVVVKQERLSPE	sumoylation	[1]
223	KEVPAKEKPSFELSG	ubiquitination	[2]
301	IDHPSCSKQHAVFQY	ubiquitination	[2]
325	GTVGRRVKPYIIDLG	ubiquitination	[2]
342	NGTFLNNKRIEPQRY	ubiquitination	[2, 3]

Reference

 [1] Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.
 Matic I, Schimmel J, Hendriks IA, van Santen MA, van de Rijke F, van Dam H, Gnad F, Mann M, Vertegaal AC.
 Mol Cell. 2010 Aug 27;39(4):641-52. [PMID: 20797634]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. 

Sequence Annotation

 DOMAIN 281 344 FHA.
 MOD_RES 35 35 Phosphoserine.
 MOD_RES 49 49 Phosphoserine.
 MOD_RES 52 52 Phosphoserine.
 MOD_RES 54 54 Phosphoserine.
 MOD_RES 394 394 Phosphoserine.
 CROSSLNK 30 30 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Coiled coil; Complete proteome; Disease mutation; Epilepsy; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; RNA-mediated gene silencing; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 396 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0035196; P:production of miRNAs involved in gene silencing by miRNA; IMP:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:Compara. 

Interpro

 IPR000253; FHA_dom.
 IPR008984; SMAD_FHA_domain. 

Pfam

 PF00498; FHA 

SMART

 SM00240; FHA 

PROSITE

 PS50006; FHA_DOMAIN 

PRINTS