| Tag | Content |
|---|
| CPLM ID | CPLM-017161 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Delta and Notch-like epidermal growth factor-related receptor |
Protein Synonyms/Alias | Brain EGF repeat-containing transmembrane protein |
Gene Name | Dner |
Gene Synonyms/Alias | Bet; Bret |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 733 | KPLVTLIKTKDL*** | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling. |
Sequence Annotation | DOMAIN 44 92 EGF-like 1.
DOMAIN 94 133 EGF-like 2.
DOMAIN 309 348 EGF-like 3.
DOMAIN 349 390 EGF-like 4.
DOMAIN 392 428 EGF-like 5.
DOMAIN 430 466 EGF-like 6.
DOMAIN 468 503 EGF-like 7.
DOMAIN 505 541 EGF-like 8; calcium-binding (Potential).
DOMAIN 543 579 EGF-like 9.
DOMAIN 581 617 EGF-like 10; calcium-binding (Potential).
REGION 44 133 Interaction with NOTCH1.
REGION 677 680 Interaction with AP1G1 and
MOD_RES 711 711 Phosphotyrosine.
MOD_RES 718 718 Phosphotyrosine.
MOD_RES 721 721 Phosphotyrosine.
CARBOHYD 204 204 N-linked (GlcNAc...) (Potential).
CARBOHYD 564 564 N-linked (GlcNAc...) (Potential).
DISULFID 48 59 By similarity.
DISULFID 53 80 By similarity.
DISULFID 82 91 By similarity.
DISULFID 98 108 By similarity.
DISULFID 103 121 By similarity.
DISULFID 123 132 By similarity.
DISULFID 319 336 By similarity.
DISULFID 338 347 By similarity.
DISULFID 353 364 By similarity.
DISULFID 358 378 By similarity.
DISULFID 380 389 By similarity.
DISULFID 396 407 By similarity.
DISULFID 401 416 By similarity.
DISULFID 418 427 By similarity.
DISULFID 434 445 By similarity.
DISULFID 439 454 By similarity.
DISULFID 456 465 By similarity.
DISULFID 472 482 By similarity.
DISULFID 477 491 By similarity.
DISULFID 493 502 By similarity.
DISULFID 509 520 By similarity.
DISULFID 514 529 By similarity.
DISULFID 531 540 By similarity.
DISULFID 547 558 By similarity.
DISULFID 552 567 By similarity.
DISULFID 569 578 By similarity.
DISULFID 585 596 By similarity.
DISULFID 590 605 By similarity.
DISULFID 607 616 By similarity. |
Keyword | Activator; Calcium; Cell membrane; Complete proteome; Developmental protein; Differentiation; Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Notch signaling pathway; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 737 AA |
Protein Sequence | MPPRRAQAPG APLLPVLALL PLLLGAGPQS GCLASPVSAA PLPAPGPCAS QPCRNGGVCT 60
PRSVTDQEHP AADAEPRYSC TCPAGVSGTY CQFVADPCAS NPCHHGNCSS SSSSSSDSYL 120
CICNDGYEGL NCEQPLPSIP TSGWTESTAP RQLQPVPATQ EPDIILPRSQ ATVTLPTWQP 180
KTGQKVVEMK WDQVEVVPDV ACGNASSNNS AGGRLVSFEV PQNTSVKIRQ DANSLLILLW 240
KVTATGFQQC SLIDGRSVTP LQAPGGLVLL EEMLALGPNH FIGFVNDSVA KSIVALRLTL 300
VVKASNCVPG DSHSNDLECS GKGKCATKPS EATFSCTCQD QYIGTFCEEF DACQRKPCQN 360
EASCIDANEK QDGSNFTCLC LPGYTGELCQ SKIDYCVLDP CRNGATCVSS LSGFTCQCLE 420
GYFGSACEEK VDPCMSSPCQ NNGTCYVDGV HFTCSCSPGF TGPTCAQLVD FCALSPCAHG 480
MCRSVGTSYK CLCDPGYHGL YCEEEYNECL SAPCLNAATC RDLINGYECV CLAEYKGTHC 540
ELYKDPCANI SCLNGGTCDS EGLNGTCICA PGFTGEECDI DINECDSNPC HHAGTCLDQP 600
NGYTCHCPHG WVGANCEIHL QWKSGHMAES LTNMPRHSLY IIIGALCVAF ILMLIILIVG 660
ICRISRIEYQ GSSRPAYEEF YNCRSIDSEF SNAIASIRHA RFGKKSRPAM YDVTPIAYED 720
YSPDDKPLVT LIKTKDL 737 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |