| Tag | Content |
|---|
| CPLM ID | CPLM-005691 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium- and chloride-dependent creatine transporter 1 |
Protein Synonyms/Alias | CHOT1; CT1; Creatine transporter 1; Solute carrier family 6 member 8 |
Gene Name | Slc6a8 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 217 | VIEFWENKVLRLSTG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity). |
Sequence Annotation | CARBOHYD 192 192 N-linked (GlcNAc...) (Potential).
CARBOHYD 197 197 N-linked (GlcNAc...) (Potential).
CARBOHYD 548 548 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 635 AA |
Protein Sequence | MAKKSAENGI YSVSGDEKKG PLIVSGPDGA PSKGDGPAGL GAPSSRLAVP PRETWTRQMD 60
FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV GGIPIFFLEI SLGQFMKAGS 120
INVWNICPLF KGLGYASMVI VFYCNTYYIM VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD 180
CVEIFRHEDC ANASLANLTC DQLADRRSPV IEFWENKVLR LSTGLEVPGA LNWEVTLCLL 240
ACWVLVYFCV WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL 300
GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG TSFFAGFVVF 360
SILGFMATEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP LWAALFFFML LLLGLDSQFV 420
GVEGFITGLL DLLPASYYFR FQREISVALC CALCFVIDLS MVTDGGMYVF QLFDYYSASG 480
TTLLWQAFWE CVVVAWVYGA DRFMDDIACM IGYRPCPWMK WCWSFFTPLV CMGIFIFNVV 540
YYKPLVYNNT YVYPWWGEAM GWAFALSSML CVPLHLLGCL LRAKGTMAER WQHLTQPIWG 600
LHHLEYRAQD ADVRGLTTLT PVSESSKVVV VESVM 635 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; IEA:InterPro. GO:0005886; C:plasma membrane; TAS:RGD. GO:0015220; F:choline transmembrane transporter activity; IDA:RGD. GO:0005309; F:creatine:sodium symporter activity; IDA:RGD. GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |