CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014650
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alanine--glyoxylate aminotransferase 2, mitochondrial 
Protein Synonyms/Alias
 AGT 2; (R)-3-amino-2-methylpropionate--pyruvate transaminase; Beta-ALAAT II; Beta-alanine-pyruvate aminotransferase; D-AIBAT 
Gene Name
 Agxt2 
Gene Synonyms/Alias
 Agt2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
69NHVLEIHKQHLSPVNacetylation[1]
82VNTAYFQKPLLLHQGacetylation[1]
127KVTAVAKKQMDRLWHacetylation[1]
302QYPKEFLKEAFALVRacetylation[1]
415VGTYMLLKFAKLRDEacetylation[1]
418YMLLKFAKLRDEFDIacetylation[1]
452ISRQPLPKTEVNQIHacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity). 
Sequence Annotation
 MOD_RES 348 348 N6-(pyridoxal phosphate)lysine (By  
Keyword
 Aminotransferase; Complete proteome; Direct protein sequencing; Mitochondrion; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 512 AA 
Protein Sequence
MSLAWRTLQK AFYLETSLRI LQMRPSLSCA SRIYVPKLTL HTKHNMPPCD FSPEKYQSLA 60
YNHVLEIHKQ HLSPVNTAYF QKPLLLHQGH MEWLFDSEGN RYLDFFSGIV TVGVGHCHPK 120
VTAVAKKQMD RLWHTSSVFF HSPMHEYAER LSALLPEPLK VIFLVNSGSE ANDLAMVMAR 180
AYSNHTDIIS FRGAYHGCSP YTLGLTNVGI YKMKVPSTIA CQSTMCPDVF RGPWGGSHCR 240
DSPVQTVRKC SCAPDGCQAK ERYIEQFKDT LNTSVATSIA GFFAEPIQGV NGVVQYPKEF 300
LKEAFALVRE RGGVCIADEV QTGFGRLGSH FWGFQTHDTM PDIVTMAKGI GNGFPMAAVV 360
TTPEIASSLA KHLHHFSTFG GSPLACAIGS AVLEVIEEEN LQRNSQEVGT YMLLKFAKLR 420
DEFDIVGDVR GKGLMVGIEM VQDKISRQPL PKTEVNQIHE DCKDMGLLVG RGGNFSQTFR 480
IAPPMRVTKL EVDFAFEVFR SALTQHMERR AK 512 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0047305; F:(R)-3-amino-2-methylpropionate-pyruvate transaminase activity; EXP:Reactome.
 GO:0008453; F:alanine-glyoxylate transaminase activity; IEA:EC.
 GO:0016223; F:beta-alanine-pyruvate transaminase activity; EXP:Reactome.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0019265; P:glycine biosynthetic process, by transamination of glyoxylate; IEA:Compara.
 GO:0009436; P:glyoxylate catabolic process; IEA:Compara.
 GO:0019481; P:L-alanine catabolic process, by transamination; IEA:Compara.
 GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Compara. 
Interpro
 IPR005814; Aminotrans_3.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00202; Aminotran_3 
SMART
  
PROSITE
 PS00600; AA_TRANSFER_CLASS_3 
PRINTS