UniProt Accession

 TF2H1_HUMAN; P32780; D3DQY2; Q6I9Y7; Q9H5K5; Q9NQD9 

Genbank Protein ID

 M95809; AK027003; AY163770; CR457368; CH471064; CH471064; BC000365; BC004452; AJ131959 

Genbank Nucleotide ID

 AAA58399.1; BAB15621.1; AAN46740.1; CAG33649.1; EAW68399.1; EAW68401.1; AAH00365.1; AAH04452.1; CAC00685.1 

Protein Name

 General transcription factor IIH subunit 1 

Protein Synonyms/Alias

 Basic transcription factor 2 62 kDa subunit; BTF2 p62; General transcription factor IIH polypeptide 1; TFIIH basal transcription factor complex p62 subunit 

Gene Name

 GTF2H1 

Gene Synonyms/Alias

 BTF2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
38	IAWAPEGKDRFTISH	ubiquitination	[1]
93	VKERDAVKDLLQQLL	ubiquitination	[2, 3, 4]
218	VPHNMTEKEFWTRFF	ubiquitination	[2, 4]
240	DRLNTGSKDLFAECA	ubiquitination	[1]
370	LGKNNSVKTIALNLK	ubiquitination	[1]
377	KTIALNLKKSDRYYH	ubiquitination	[1]
504	LERFQVTKLCPFQEK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. 

Sequence Annotation

 DOMAIN 99 154 BSD 1.
 DOMAIN 180 232 BSD 2.  

Keyword

 3D-structure; Complete proteome; DNA damage; DNA repair; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 548 AA 

Protein Sequence

Gene Ontology

 GO:0000439; C:core TFIIH complex; IEA:InterPro.
 GO:0005675; C:holo TFIIH complex; IDA:UniProtKB.
 GO:0006370; P:7-methylguanosine mRNA capping; TAS:Reactome.
 GO:0000718; P:nucleotide-excision repair, DNA damage removal; TAS:Reactome.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0050434; P:positive regulation of viral transcription; TAS:Reactome.
 GO:0006468; P:protein phosphorylation; IDA:GOC.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; TAS:ProtInc.
 GO:0006363; P:termination of RNA polymerase I transcription; TAS:Reactome.
 GO:0006362; P:transcription elongation from RNA polymerase I promoter; TAS:Reactome.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.
 GO:0006361; P:transcription initiation from RNA polymerase I promoter; TAS:Reactome.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
 GO:0006283; P:transcription-coupled nucleotide-excision repair; TAS:Reactome.
 GO:0022415; P:viral reproductive process; TAS:Reactome. 

Interpro

 IPR005607; BSD.
 IPR011993; PH_like_dom.
 IPR027079; Tfb1/p62.
 IPR013876; TFIIH_BTF_p62_N. 

Pfam

 PF03909; BSD
 PF08567; TFIIH_BTF_p62_N 

SMART

 SM00751; BSD 

PROSITE

 PS50858; BSD 

PRINTS