UniProt Accession

 SAT2_HUMAN; Q96F10 

Genbank Protein ID

 AF348524; BC011751 

Genbank Nucleotide ID

 AAL83905.1; AAH11751.1 

Protein Name

 Diamine acetyltransferase 2 

Protein Synonyms/Alias

 Polyamine N-acetyltransferase 2; Spermidine/spermine N(1)-acetyltransferase 2; Thialysine N-epsilon-acetyltransferase 

Gene Name

 SAT2 

Gene Synonyms/Alias

 SSAT2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
29	RELAEFEKLSDQVKI	acetylation	[1, 2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine. 

Sequence Annotation

 DOMAIN 4 168 N-acetyltransferase.
 REGION 27 28 Substrate binding (By similarity).
 REGION 94 96 Acetyl-CoA binding.
 REGION 102 107 Acetyl-CoA binding.
 REGION 133 135 Acetyl-CoA binding.
 BINDING 92 92 Substrate; via carbonyl oxygen (By
 BINDING 140 140 Acetyl-CoA.
 BINDING 152 152 Substrate (By similarity).
 MOD_RES 29 29 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Acyltransferase; Complete proteome; Cytoplasm; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 170 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004145; F:diamine N-acetyltransferase activity; IEA:EC.
 GO:0009447; P:putrescine catabolic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR016181; Acyl_CoA_acyltransferase.
 IPR000182; GNAT_dom. 

Pfam

 PF00583; Acetyltransf_1 

SMART

  

PROSITE

 PS51186; GNAT 

PRINTS