CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017312
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 L-fucose kinase 
Protein Synonyms/Alias
 Fucokinase 
Gene Name
 FUK 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
52LAVEDPEKRVGSGGAubiquitination[1]
496VPWSEFFKRTGVRAWubiquitination[1, 2]
691ALAQERDKWLSRPALubiquitination[1]
806RQDEMTVKIVCRCLAubiquitination[1]
913SRAQLPLKVEVEEVTubiquitination[2]
940LLLVYTGKTRLARNLubiquitination[1, 2]
1000TSYWEQKKLMAPGCEubiquitination[1]
1046LTKEPQQKEALEAVLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides. 
Sequence Annotation
 NP_BIND 834 845 ATP (Potential).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1084 AA 
Protein Sequence
MEQPKGVDWT VIILTCQYKD SVQVFQRELE VRQKREQIPA GTLLLAVEDP EKRVGSGGAT 60
LNALLVAAEH LSARAGFTWI CVGVSLWIRG CHPPGRLPEA SVHRAFPLLQ VVTSDVLHSA 120
WILILHMGRD FPFDDCGRAF TCLPVENPEA PVEALVCNLD CLLDIMTYRL GPGSPPGVWV 180
CSTDMLLSVP ANPGISWDSF RGARVIALPG SPAYAQNHGV YLTDPQGLVL DIYYQGTEAE 240
IQRCVRPDGR VPLVSGVVFF SVETAERLLA THVSPPLDAC TYLGLDSGAR PVQLSLFFDI 300
LHCMAENVTR EDFLVGRPPE LGQGDADVAG YLQSARAQLW RELRDQPLTM AYVSSGSYSY 360
MTSSASEFLL SLTLPGAPGA QIVHSQVEEQ QLLAAGSSVV SCLLEGPVQL GPGSVLQHCH 420
LQGPIHIGAG CLVTGLDTAH SKALHGRELR DLVLQGHHTR LHGSPGHAFT LVGRLDSWER 480
QGAGTYLNVP WSEFFKRTGV RAWDLWDPET LPAEYCLPSA RLFPVLHPSR ELGPQDLLWM 540
LDHQEDGGEA LRAWRASWRL SWEQLQPCLD RAATLASRRD LFFRQALHKA RHVLEARQDL 600
SLRPLIWAAV REGCPGPLLA TLDQVAAGAG DPGVAARALA CVADVLGCMA EGRGGLRSGP 660
AANPEWMRPF SYLECGDLAA GVEALAQERD KWLSRPALLV RAARHYEGAG QILIRQAVMS 720
AQHFVSTEQV ELPGPGQWVV AECPARVDFS GGWSDTPPLA YELGGAVLGL AVRVDGRRPI 780
GARARRIPEP ELWLAVGPRQ DEMTVKIVCR CLADLRDYCQ PHAPGALLKA AFICAGIVHV 840
HSELQLSTSS ILAGTALAAL QRAAGRVVGT EALIHAVLHL EQVLTTGGGW QDQVGGLMPG 900
IKVGRSRAQL PLKVEVEEVT VPEGFVQKLN DHLLLVYTGK TRLARNLLQD VLRSWYARLP 960
AVVQNAHSLV RQTEECAEGF RQGSLPLLGQ CLTSYWEQKK LMAPGCEPLT VRRMMDVLAP 1020
HVHGQSLAGA GGGGFLYLLT KEPQQKEALE AVLAKTEGLG NYSIHLVEVD TQGLSLKLLG 1080
TEASTCCPFP 1090 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0050201; F:fucokinase activity; NAS:UniProtKB. 
Interpro
 IPR012887; Fucokinase.
 IPR013750; GHMP_kinase_C_dom.
 IPR006204; GHMP_kinase_N_dom.
 IPR006206; Mevalonate/galactokinase.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr. 
Pfam
 PF07959; Fucokinase
 PF08544; GHMP_kinases_C
 PF00288; GHMP_kinases_N 
SMART
  
PROSITE
 PS00627; GHMP_KINASES_ATP 
PRINTS
 PR00959; MEVGALKINASE.