| Tag | Content |
|---|
| CPLM ID | CPLM-001612 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | GDH/6PGL endoplasmic bifunctional protein |
Protein Synonyms/Alias | Glucose 1-dehydrogenase; Hexose-6-phosphate dehydrogenase; 6-phosphogluconolactonase; 6PGL |
Gene Name | H6PD |
Gene Synonyms/Alias | GDH |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 122 | EDYQALNKDIEAQLQ | ubiquitination | [1] | | 223 | PFRDQNRKALDGLWN | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates. |
Sequence Annotation | REGION 20 526 Glucose 1-dehydrogenase.
REGION 527 540 Linker.
REGION 541 791 6-phosphogluconolactonase.
ACT_SITE 267 267 Proton acceptor (By similarity).
BINDING 34 34 NADP (By similarity).
BINDING 66 66 NADP (By similarity).
BINDING 204 204 Substrate (By similarity).
BINDING 208 208 Substrate (By similarity).
MOD_RES 20 20 Pyrrolidone carboxylic acid (By
CARBOHYD 157 157 N-linked (GlcNAc...).
CARBOHYD 282 282 N-linked (GlcNAc...).
CARBOHYD 683 683 N-linked (GlcNAc...) (Potential). |
Keyword | Carbohydrate metabolism; Complete proteome; Disease mutation; Endoplasmic reticulum; Glucose metabolism; Glycoprotein; Hydrolase; Multifunctional enzyme; NAD; NADP; Oxidoreductase; Polymorphism; Pyrrolidone carboxylic acid; Reference proteome; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 791 AA |
Protein Sequence | MWNMLIVAMC LALLGCLQAQ ELQGHVSIIL LGATGDLAKK YLWQGLFQLY LDEAGRGHSF 60
SFHGAALTAP KQGQELMAKA LESLSCPKDM APSHCAEHKD QFLQLSQYRQ LKTAEDYQAL 120
NKDIEAQLQH AGLREAGRIF YFSVPPFAYE DIARNINSSC RPGPGAWLRV VLEKPFGHDH 180
FSAQQLATEL GTFFQEEEMY RVDHYLGKQA VAQILPFRDQ NRKALDGLWN RHHVERVEII 240
MKETVDAEGR TSFYEEYGVI RDVLQNHLTE VLTLVAMELP HNVSSAEAVL RHKLQVFQAL 300
RGLQRGSAVV GQYQSYSEQV RRELQKPDSF HSLTPTFAAV LVHIDNLRWE GVPFILMSGK 360
ALDERVGYAR ILFKNQACCV QSEKHWAAAQ SQCLPRQLVF HIGHGDLGSP AVLVSRNLFR 420
PSLPSSWKEM EGPPGLRLFG SPLSDYYAYS PVRERDAHSV LLSHIFHGRK NFFITTENLL 480
ASWNFWTPLL ESLAHKAPRL YPGGAENGRL LDFEFSSGRL FFSQQQPEQL VPGPGPAPMP 540
SDFQVLRAKY RESPLVSAWS EELISKLAND IEATAVRAVR RFGQFHLALS GGSSPVALFQ 600
QLATAHYGFP WAHTHLWLVD ERCVPLSDPE SNFQGLQAHL LQHVRIPYYN IHPMPVHLQQ 660
RLCAEEDQGA QIYAREISAL VANSSFDLVL LGMGADGHTA SLFPQSPTGL DGEQLVVLTT 720
SPSQPHRRMS LSLPLINRAK KVAVLVMGRM KREITTLVSR VGHEPKKWPI SGVLPHSGQL 780
VWYMDYDAFL G 791 |
Gene Ontology | GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IEA:Compara. GO:0017057; F:6-phosphogluconolactonase activity; IEA:EC. GO:0030246; F:carbohydrate binding; IEA:Compara. GO:0047936; F:glucose 1-dehydrogenase [NAD(P)] activity; IEA:EC. GO:0004345; F:glucose-6-phosphate dehydrogenase activity; TAS:ProtInc. GO:0050661; F:NADP binding; IEA:Compara. GO:0006098; P:pentose-phosphate shunt; IEA:Compara. GO:0097305; P:response to alcohol; IEA:Compara. |
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