CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038974
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase UBR4 
Protein Synonyms/Alias
  
Gene Name
 Ubr4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1151AAETDPHKSSEITKNubiquitination[1]
1931LQLSALLKQADSSKRacetylation[2]
3827NSFDELSKIIQKVFAacetylation[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5194 AA 
Protein Sequence
MATSGGEEAA AAAPAPGAPA TGQDTTPGWE VAVRPLLSAS YSAFEMKELP QLVASVIESE 60
SEILHHEKQY EPFYSSFVAL STHYITTVCS LIPRNQLQSV AAACKVLIEF SLLRLENPDE 120
ACAVSQKHLI LLIKGLCTGC SRLDRTEIIT FTAMMKSAKL PQTVKTLSDV EDQKELASPV 180
SPELRQKEVQ MNFLNQLTSV FNPRTVPSPP ISPQALVEGE NDEQSSTEQA SAVKTKNVFI 240
AQNVASLQEL GGSEKLLRVC LNLPYFLRYI NRFQDAVVAN SFFIMPATVA DATAVRNGFH 300
SLVIDVTMAL DTLSLPVLEP LNPSRLQDVT VLSLSCLYAG VSVATCMAIL HVGSAQQVRT 360
GSTSSKEEDY ESDAATIVQK CLEIYDMIGQ AISSSRRAGG EHFQNFQLLG AWCLLNSLFL 420
ILHLSPTALA DKGKEKDPLA ALRVRDILSR TKEGVGSPKL GPGKGHQGFG VLSVILANHA 480
IKLLTSLFQD LQVEALHKGW ETDGPPAVLS IMAQSTSTQR VQRLIDSVPL TNLLLTLLST 540
SYRKACVLQR QRKGSMSSDA SASTDSNTYY EDDFSSTEED SSQDDDSEPI LGQWFEETIS 600
PSKEKAAPPP PPPPPPLESS PRVKSPSKQA SGEKGNILAS RKDPELFLGL ASNILNFITS 660
SMLNSRNNFI RNYLSVSLSE QHMATLASII KEVDKDGLKG SSDEDFAAAL YHFNHSLVTS 720
DLQSPNLQNT LLQQLGVAPL SSGPWPLYIH PQGLSVLSRL LLIWQHKAGA QGDPDVPECL 780
KVWDRFLTTM KQSALQGVVP SETEDLNIEH LQLLLLIFHS FSEKGRRAIL TTLVQSIQEL 840
SVNMEVQMRS APLILARLLL IFDYLLHQYS KAPVYLFEQV QHNLLSPPFG WASGSQDSSS 900
SSRRANIPLY HGFKEVEENW SKHFSSDAAP QPRFYCVLST EASEEDLNRL DSEACEVLFS 960
KLVKYDELYS SLTALLAAGS QLDTVKRKEN KNMTALEACA LQYYFLILWR ILGILPPSKT 1020
YMNQLAMNSP EMSECDILHT LRWSSRLRIS SYVSWIKDHL IRQGMRPEHA GSLVELAASK 1080
CSSVKYDVEI VEEYFARQIS SFCSIDCTTV LQLHEIPSLQ SIYTLDAAVS KVQVSLDEHF 1140
SKMAAETDPH KSSEITKNLL PATLQLIDTY ASFTRAYLLQ NLNEEGSTEK PSQEKLHGFA 1200
AVLAIGSSRC KANTLGPTLV QNLPSSVQSV CESWNNINTN EFPNIGSWRN AFANDTIPSE 1260
SYISAVQAAH LGTLCGQSLP LAASLKHALL SLVRLTGDLI VWSDEMNPAQ VIRALLPLLL 1320
ESSTESAAEI SSNSLERILG PAESDEFLAR VYEKLITGCY NILANHADPS SGLDESVLEE 1380
CLQYLEKQLE SSQARKAMEE FFSDGGELVQ IMMATANEDL SAKFCNRVLK FFTKLFQLTE 1440
KSPNPSLLHL CGSLAQLACV EPVRLQAWLT RMTTSPPKDS DQLEVIQENR QLLQLLTTYI 1500
VRENSQVGEG VCAVLLGTLT PMATDMLANG DGTGFPELMV VMATLASAGQ GAGHLQLHNA 1560
AVDWLGRCKK YLSQKNVVEK LNANVMHGKH VMVLECTCHI MSYLADVTNA LSQSNGQGPS 1620
HLSVDGEERA IEVDSDWVEE LAVEEEDSQA EDSDEDSLCN KLCTFTITQK EFMNQHWYHC 1680
HTCKMVDGVG VCTVCAKVCH KDHEISYAKY GSFFCDCGAK EDGSCLALVK RTPSSGMSST 1740
MKESAFQSEP RVSESLVRHA STSPADKAKV TISDGKVADE EKPKKSSLCR TVEGCREELQ 1800
NQANFSFAPL VLDMLNFLMD AIQTNFQQAS AVGSSSRAQQ ALSELHTVDK VVEMTDQLMV 1860
PTLGSQEGAF ENVRMNYSGD QGQTIRQLIS AHVLRRVAMC VLSSPHGRRQ HLAVSHEKGK 1920
ITVLQLSALL KQADSSKRKL TLTRLASAPV PFTVLSLTGN PCKEDYLAVC GLKDCHVLTF 1980
SSSGSVSDHL VLHPQLATGN FIIKAVWLPG SQTELAIVTA DFVKIYDLSV DALSPTFYFL 2040
LPSSKIRDVT FLFNEEGKNI IVIMSSAGYM YTQLMEEASS AQQGPFYVTN VLEINHEDLK 2100
DSNSQVAGGG VSVYYSHVLQ MLFFSYSQGK SFAATVSRST LEVLQLFPIN IKSSNGGSKT 2160
SPALCQWSEV MNHPGLVCCV QQTTGVPLVV MVKPDTFLIQ EIKTLPAKAK IQDMVAIRHT 2220
ACNEQQRTTM ILLCEDGSLR IYMANVENTS YWLQPSLQPS SVISIMKPVR KRKTATITAR 2280
TSSQVTFPID FFEHNQQLTD VEFGGNDLLQ VYNAQQIKHR LNSTGMYVAN TKPGGFTMEI 2340
SNNSSTMVMT GMRIQIGTQA IERAPSYIEI FGRTMQLNLS RSRWFDFPFT REEALQADRK 2400
LNLFIGASVD PAGVTMIDAV KIYGKTKEQF GWPDEPPEDF PSASVSSVCP PNLNQSNSTG 2460
DSDSAAPATT SGTVLERLVV SSLEALESCF AVGPIIEKER NKHAAQELAT LLLSLPAPAS 2520
VQQQSKSLLA SLHSSRSAYH SHKDQALLSK AVQCLNTSSK EGKDLDPEVF QRLVITARSI 2580
AVTRPNNLVH FTESKLPQME TEGAEEGKEP QKQVEGDGCS FITQLVNHFW KLHASKPKNA 2640
FLAPACLPGL THIEATVNAL VDIIHGYCTC ELDCINTASK IYMQMLLCPD PAVSFSCKQA 2700
LIRVLRPRNK RRHVTLPSSP RSNTPMGDKD DDDDDDADEK MQSSGIPDGG HIRQESQEQS 2760
EVDHGDFEMV SESMVLETAE NVNNGNPSPL EALLAGAEGF PPMLDIPPDA DDETMVELAI 2820
ALSLQQDQQG SSSSALGLQS LGLSGQAPSS SSLDAGTLSD TTASGVCACN SSVTLSAPAS 2880
DDEGSTAATD GSTLRTSPAD HGGSVGSESG GSAVDSVAGE HSVSGRSSAY GDATAEGHPA 2940
GPGSVSSSTG AISTTTGHQE GDGSEGEGEG EAEGDVHTSN RLHMVRLMLL ERLLQTLPQL 3000
RNVGGVRAIP YMQVILMLTT DLDGEDEKDK GALDNLLAQL IAELGMDKKD VSKKNERSAL 3060
NEVHLVVMRL LSVFMSRTKS GSKSSICESS SLISSATAAA LLSSGAVDYC LHVLKSLLEY 3120
WKGQQSEEEP VTTSQLLKPH TTSSPPDMSP FFLRQYVKGH AADVFEAYTQ LLTEMVLRLP 3180
YQIKKIADTS SRIPPPVFDH SWFYFLSEYL MIQQTPFVRR QVRKLLLFIC GSKEKYRQLR 3240
DLHTLDSHVR GIKKLLEEQG IFLRASVVTA SSGSALQYDT LISLMEHLKA CAEIAAQRTI 3300
NWQKFCIKDD SVLYFLLQVS FLVDEGVSPV LLQLLSCALC GSKVLAALAA STGSSSVASS 3360
APPAASSGQT TTQSKSSTKK SKKEEKEKEK EGESSGSQED QLCTALVNQL NRFADKETLI 3420
QFLRCFLLES NSSSVRWQAH CLTLHIYRNS NKAQQELLLD LMWSIWPELP AYGRKAAQFV 3480
DLLGYFSLKT AQTEKKLKEY SQKAVEILRT QNHILTNHPN SNIYNTLSGL VEFDGYYLES 3540
DPCLVCNNPE VPFCYIKLSS IKVDTRYTTT QQVVKLIGSH TISKVTVKIG DLKRTKMVRT 3600
INLYYNNRTV QAIVELKNKP ARWHKAKKVQ LTPGQTEVKI DLPLPIVASN LMIEFADFYE 3660
NYQASTETLQ CPRCSASVPA NPGVCGNCGE NVYQCHKCRS INYDEKDPFL CNACGFCKYA 3720
RFDFMLYAKP CCAVDPIENE EDRKKAVSNI NTLLDKADRV YHQLMGHRPQ LENLLCKVNE 3780
AAPEKPQEDS GTAGGISSTS ASVNRYILQL AQEYCGDCKN SFDELSKIIQ KVFASRKELL 3840
EYDLQQREAA TKSSRTSVQP TFTASQYRAL SVLGCGHTSS TKCYGCASAV TEHCITLLRA 3900
LATNPALRHI LVSQGLIREL FDYNLRRGAA AIREEVRQLM CLLTRDNPEA TQQMNDLIIG 3960
KVSTALKGHW ANPDLASSLQ YEMLLLTDSI SKEDSCWELR LRCALSLFLM AVNIKTPVVV 4020
ENITLMCLRI LQKLIKPPAP TSKKNKDVPV EALTTVKPYC NEIHAQAQLW LKRDPKASYE 4080
AWKKCLPIRG VDGNGKSPSK SELHRLYLTE KYVWRWKQFL SRRGKRTTPL DLKLGHNNWL 4140
RQVLFTPATQ AARQAACTIV EALATVPSRK QQVLDLLTSY LDELSVAGEC AAEYLALYQK 4200
LIASCHWKVY LAARGVLPYV GNLITKEIAR LLALEEATLS TDLQQGYALK SLTGLLSSFV 4260
EVESIKRHFK SRLVGTVLNG YLCLRKLVLQ RTKLIDETQD MLLEMLEDMT TGTESETKAF 4320
MAVCIETAKR YNLDDYRTPV FIFERLCSII YPEENEVTEF FVTLEKDPQQ EDFLQGRMPG 4380
NPYSSNEPGI GPLMRDIKNK ICQDCDLVAL LEDDSGMELL VNNKIISLDL PVAEVYKKVW 4440
CTTNEGEPMR IVYRMRGLLG DATEEFIESL DSTTDEEEDE EEVYRMAGVM AQCGGLQCML 4500
NRLAGVKDFK QGRHLLTVLL KLFSYCVKVK VNRQQLVKLE MNTLNVMLGT LNLALVAEQE 4560
SKDSGGAAVA EQVLSIMEII LDESNAEPLS EDKGNLLLTG DKDQLVMLLD QINSTFVRSN 4620
PSVLQGLLRI IPYLSFGEVE KMQILVERFK PYCSFDKYDE DHSGDDKVFL DCFCKIAAGI 4680
KNNSNGHQLK DLILQKGITQ SALDYMKKHI PSAKNLDADI WKKFLSRPAL PFILRLLRGL 4740
AMQHPATQVL IGTDSITSLH KLEQVSSDEG IGTLAENLLE ALREHPDVNK KIDAARRETR 4800
AEKKRMAMAM RQKALGTLGM TTNEKGQVVT KTALLKQMEE LIEEPGLTCC ICREGYKFQP 4860
TKVLGIYTFT KRVALEEMEN KPRKQQGYST VSHFNIVHYD CHLAAVRLAR GREEWESAAL 4920
QNANTKCNGL LPVWGPHVPE SAFATCLARH NTYLQECTGQ REPTYQLNIH DIKLLFLRFA 4980
MEQSFSADTG GGGRESNIHL IPYIIHTVLY VLNTTRATSR EEKNLQGFLE QPREKWTESA 5040
FDVDGPHYFT ILALHVLPPE QWKATRVEIL RRLLVASHAR AVAPGGATRL TDKAVKDYSA 5100
YRSSLLFWAL VDLIYNMFKK VPTSNTEGGW SCSLAEYIRH NDMPIYEAAD KALKTFQEEF 5160
MPVETFSEFL DAAGLLSEIT DPESFLKDLL NSVP 5194 
Gene Ontology
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:GOC. 
Interpro
 IPR025704; E3_Ub_ligase_UBR4.
 IPR003126; Znf_N-recognin. 
Pfam
 PF13764; E3_UbLigase_R4
 PF02207; zf-UBR 
SMART
  
PROSITE
 PS51157; ZF_UBR 
PRINTS