CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018363
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Progesterone-induced-blocking factor 1 
Protein Synonyms/Alias
  
Gene Name
 PIBF1 
Gene Synonyms/Alias
 C13orf24; PIBF 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
99LNDALHQKQLLTLRLubiquitination[1]
115NQLAFQQKDASKYQEubiquitination[1, 2]
168LTEEQYIKLKAFPEDubiquitination[1]
251ALELADTKQLIQQGDubiquitination[1, 2]
352QAQLEESKKAREEMYubiquitination[1]
387ELEQIRLKTNQEIDQubiquitination[1, 3]
434AEKDALEKHDQLLDRubiquitination[1]
461TEFLHQSKLKSFESEubiquitination[1]
463FLHQSKLKSFESERVubiquitination[1]
490QCQLECEKYQKKLEVubiquitination[1, 3]
494ECEKYQKKLEVLTKEubiquitination[1]
571ANVPTTAKRRLKQSVubiquitination[1, 2]
589RRVLQLEKQNSLILKubiquitination[1]
708ENSLLLTKTEPKHVTubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 757 AA 
Protein Sequence
MSRKISKESK KVNISSSLES EDISLETTVP TDDISSSEER EGKVRITRQL IERKELLHNI 60
QLLKIELSQK TMMIDNLKVD YLTKIEELEE KLNDALHQKQ LLTLRLDNQL AFQQKDASKY 120
QELMKQEMET ILLRQKQLEE TNLQLREKAG DVRRNLRDFE LTEEQYIKLK AFPEDQLSIP 180
EYVSVRFYEL VNPLRKEICE LQVKKNILAE ELSTNKNQLK QLTETYEEDR KNYSEVQIRC 240
QRLALELADT KQLIQQGDYR QENYDKVKSE RDALEQEVIE LRRKHEILEA SHMIQTKERS 300
ELSKEVVTLE QTVTLLQKDK EYLNRQNMEL SVRCAHEEDR LERLQAQLEE SKKAREEMYE 360
KYVASRDHYK TEYENKLHDE LEQIRLKTNQ EIDQLRNASR EMYERENRNL REARDNAVAE 420
KERAVMAEKD ALEKHDQLLD RYRELQLSTE SKVTEFLHQS KLKSFESERV QLLQEETARN 480
LTQCQLECEK YQKKLEVLTK EFYSLQASSE KRITELQAQN SEHQARLDIY EKLEKELDEI 540
IMQTAEIENE DEAERVLFSY GYGANVPTTA KRRLKQSVHL ARRVLQLEKQ NSLILKDLEH 600
RKDQVTQLSQ ELDRANSLLN QTQQPYRYLI ESVRQRDSKI DSLTESIAQL EKDVSNLNKE 660
KSALLQTKNQ MALDLEQLLN HREELAAMKQ ILVKMHSKHS ENSLLLTKTE PKHVTENQKS 720
KTLNVPKEHE DNIFTPKPTL FTKKEAPEWS KKQKMKT 757 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB. 
Interpro
 IPR026205; PIBF1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS