CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018500
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinesin-like protein KIF18A 
Protein Synonyms/Alias
  
Gene Name
 Kif18a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
448LKLEMLLKANALKSSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression (By similarity). 
Sequence Annotation
 DOMAIN 1 283 Kinesin-motor.
 NP_BIND 113 120 ATP (By similarity).
 MOD_RES 674 674 Phosphoserine (By similarity).  
Keyword
 ATP-binding; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Glycoprotein; Microtubule; Motor protein; Nucleotide-binding; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Transport; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 886 AA 
Protein Sequence
MSGTEEDLCH RMKVVVRVRP ENTKEKAVQF CKVVHVVDKH ILSFDPKQEE ISFFHRKKTT 60
NFDITKRQNK DLKFVFDAVF DETSTQMEVF EHTTKPILHS FLNGYNCTVF AYGATGSGKT 120
HTMLGSAAEP GVMYLTMLDL FKCIDEIKEE KECSTAVSYL EVYNEQIRDL LTNSGPLAVR 180
EDSQKGVVVQ GLTLHQPKSS EEILQLLDNG NKNRTQHPTD VNAVSSRSHA VFQIYLRQQD 240
KTASINQNVR IAKMSLIDLA GSERASVSGA KGSRFVEGTN INKSLLALGN VINALANTKR 300
RNQHIPYRNS KLTRLLKDSL GGNCQTIMIA AVSPSSLFYD DTYNTLKYAN RAKEIKSSLK 360
SNVLNLNSHI SQYVKICNMQ KAEILMLKEK LKAYEEQKAL SDRNDCAKLV HSNPEDRETE 420
RFQEILNCLF QNREGIRQEY LKLEMLLKAN ALKSSYHQQC HKQIEMMCSE DKVEKATCKR 480
DHRLEKLKTN SCFLEKKKEE VSKQFDENTN WLHRVENEMR LLGQNGDIPE ALNKELHCHH 540
LHLQNKELKT QMAHMTALAC LQEQQHKQTE AVLNALLPVL RKQYWKLKET GLSNAAFDSD 600
FKDIEHLVER KKVVAWADQT NEHSNRNDLP GISLLMTFPQ LEPIQSISCC TSVSDPNVLK 660
LTPQRRTRRK IIPSPLKVQH TQKSALSEST QLNDSFSKEL QPIVYTPEDC KKAQDLFPSL 720
TRTSSQSANV MNDNSQKALC RIESPLSRTE CKQGLYSTST LCDSIRGLKN KWPEQEPLAS 780
SKSSVHRIES SSFSTKDSMP ESAGVPSYMA MTTAAKRKWK QMSSTSNASI KSDESCGFAK 840
RIRRDNSSVK PMQENRLKVG YKRNTNKTNS NMLRKFRRNT SKENVQ 886 
Gene Ontology
 GO:0005901; C:caveola; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005828; C:kinetochore microtubule; ISS:UniProtKB.
 GO:0005875; C:microtubule associated complex; IEA:InterPro.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0001726; C:ruffle; ISS:UniProtKB.
 GO:0003779; F:actin binding; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0051010; F:microtubule plus-end binding; ISS:UniProtKB.
 GO:0008574; F:plus-end-directed microtubule motor activity; ISS:UniProtKB.
 GO:0070463; F:tubulin-dependent ATPase activity; ISS:UniProtKB.
 GO:0043130; F:ubiquitin binding; ISS:UniProtKB.
 GO:0007019; P:microtubule depolymerization; ISS:UniProtKB.
 GO:0007018; P:microtubule-based movement; IEA:InterPro.
 GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00225; Kinesin 
SMART
 SM00129; KISc 
PROSITE
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2 
PRINTS
 PR00380; KINESINHEAVY.