CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000255
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AP-3 complex subunit delta-1 
Protein Synonyms/Alias
 AP-3 complex subunit delta; Adapter-related protein complex 3 subunit delta-1; Delta-adaptin 
Gene Name
 AP3D1 
Gene Synonyms/Alias
 PRO0039 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
4****MALKMVKGSIDubiquitination[1]
7*MALKMVKGSIDRMFubiquitination[1]
16SIDRMFDKNLQDLVRubiquitination[1, 2]
44SQCIDEIKQELKQDNubiquitination[1]
55KQDNIAVKANAVCKLubiquitination[1]
176IMYKVFLKYPESLRPubiquitination[1, 2]
189RPAFPRLKEKLEDPDubiquitination[1]
191AFPRLKEKLEDPDPGubiquitination[1]
352ILQCLDDKDESIRLRubiquitination[1]
610ELNPVAPKAQKKVPVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. 
Sequence Annotation
 REPEAT 34 71 HEAT 1.
 REPEAT 77 114 HEAT 2.
 REPEAT 142 179 HEAT 3.
 REPEAT 180 216 HEAT 4.
 REPEAT 254 292 HEAT 5.
 REPEAT 299 336 HEAT 6.
 REPEAT 338 373 HEAT 7.
 REPEAT 375 409 HEAT 8.
 REPEAT 431 468 HEAT 9.
 REPEAT 497 535 HEAT 10.
 REPEAT 548 585 HEAT 11.
 MOD_RES 632 632 Phosphoserine.
 MOD_RES 634 634 Phosphoserine.
 MOD_RES 636 636 Phosphoserine.
 MOD_RES 658 658 Phosphoserine.
 MOD_RES 688 688 Phosphoserine.
 MOD_RES 758 758 Phosphoserine.
 MOD_RES 759 759 Phosphoserine.
 MOD_RES 762 762 Phosphothreonine.
 MOD_RES 764 764 Phosphoserine.
 MOD_RES 788 788 Phosphoserine.
 MOD_RES 829 829 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Repeat; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1153 AA 
Protein Sequence
MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC 60
KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIRKDL 120
SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIM YKVFLKYPES 180
LRPAFPRLKE KLEDPDPGVQ SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK 240
IIKLFGALTP LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS 300
IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD DKDESIRLRA 360
LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI IDICSQSNYQ YITNFEWYIS 420
ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA IRKFAVSQMS ALLDSAHLLA SSTQRNGICE 480
VLYAAAWICG EFSEHLQEPH HTLEAMLRPR VTTLPGHIQA VYVQNVVKLY ASILQQKEQA 540
GEAEGAQAVT QLMVDRLPQF VQSADLEVQE RASCILQLVK HIQKLQAKDV PVAEEVSALF 600
AGELNPVAPK AQKKVPVPEG LDLDAWINEP LSDSESEDER PRAVFHEEEQ RRPKHRPSEA 660
DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDTPGVE HIPVVQIDLS VPLKVPGLPM 720
SDQYVKLEEE RRHRQKLEKD KRRKKRKEKE KKGKRRHSSL PTESDEDIAP AQQVDIVTEE 780
MPENALPSDE DDKDPNDPYR ALDIDLDKPL ADSEKLPIQK HRNTETSKSP EKDVPMVEKK 840
SKKPKKKEKK HKEKERDKEK KKEKEKKAED LDFWLSTTPP PAPAPAPAPV PSTGELSVNT 900
VTTPKDECED AKTEAQGEED DAEGQDQDKK SPKPKKKKHR KEKEERTKGK KKSKKQPPGS 960
EEAAGEPVQN GAPEEEQLPP ESSYSLLAEN SYVKMTCDIR GSLQEDSQVT VAIVLENRSS 1020
SILKGMELSV LDSLNARMAR PQGSSVHDGV PVPFQLPPGV SNEAQYVFTI QSIVMAQKLK 1080
GTLSFIAKND EGATHEKLDF RLHFSCSSYL ITTPCYSDAF AKLLESGDLS MSSIKVDGIR 1140
MSFQNLLAKI CFHHHFSVVE RVDSCASMYS RSIQGHHVCL LVKKGENSVS VDGKCSDSTL 1200
LSNLLEEMKA TLAKC 1215 
Gene Ontology
 GO:0010008; C:endosome membrane; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; TAS:ProtInc.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0030117; C:membrane coat; IEA:InterPro.
 GO:0043195; C:terminal bouton; IEA:Compara.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0005215; F:transporter activity; TAS:ProtInc.
 GO:0008089; P:anterograde axon cargo transport; ISS:UniProtKB.
 GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
 GO:0048007; P:antigen processing and presentation, exogenous lipid antigen via MHC class Ib; IEA:Compara.
 GO:0006726; P:eye pigment biosynthetic process; TAS:ProtInc.
 GO:0006886; P:intracellular protein transport; TAS:ProtInc.
 GO:0051138; P:positive regulation of NK T cell differentiation; IEA:Compara.
 GO:0033365; P:protein localization to organelle; IEA:Compara.
 GO:0061088; P:regulation of sequestering of zinc ion; IMP:BHF-UCL.
 GO:0048499; P:synaptic vesicle membrane organization; IEA:Compara. 
Interpro
 IPR017105; AP3_complex_dsu.
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR010474; BLV_receptor.
 IPR002553; Clathrin/coatomer_adapt-like_N. 
Pfam
 PF01602; Adaptin_N
 PF06375; BLVR 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS