UniProt Accession

 DAPE_ECOLI; P0AED7; P24176 

Genbank Protein ID

 S41760; X57403; U00096; AP009048 

Genbank Nucleotide ID

 AAB22798.1; CAA40665.1; AAC75525.1; BAA16346.1 

Protein Name

 Succinyl-diaminopimelate desuccinylase 

Protein Synonyms/Alias

 SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase 

Gene Name

 dapE 

Gene Synonyms/Alias

 msgB; b2472; JW2456 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
277	QVLALLEKHQLRYTV	acetylation	[1]
299	PFLTARGKLVDAVVN	acetylation	[1]
315	VEHYNEIKPQLLTTG	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. 

Sequence Annotation

 ACT_SITE 68 68 By similarity.
 ACT_SITE 133 133 Proton acceptor (By similarity).
 METAL 66 66 Cobalt or zinc 1 (By similarity).
 METAL 99 99 Cobalt or zinc 1 (By similarity).
 METAL 99 99 Cobalt or zinc 2 (By similarity).
 METAL 134 134 Cobalt or zinc 2 (By similarity).
 METAL 162 162 Cobalt or zinc 1 (By similarity).
 METAL 348 348 Cobalt or zinc 2 (By similarity).  

Keyword

 Amino-acid biosynthesis; Cobalt; Complete proteome; Diaminopimelate biosynthesis; Hydrolase; Lysine biosynthesis; Metal-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 375 AA 

Protein Sequence

Gene Ontology

 GO:0050897; F:cobalt ion binding; IEA:HAMAP.
 GO:0008237; F:metallopeptidase activity; IEA:InterPro.
 GO:0009014; F:succinyl-diaminopimelate desuccinylase activity; IMP:EcoliWiki.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:0019877; P:diaminopimelate biosynthetic process; IEA:HAMAP.
 GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:HAMAP.
 GO:0006508; P:proteolysis; IEA:InterPro. 

Interpro

 IPR001261; ArgE/DapE_CS.
 IPR005941; DapE_proteobac.
 IPR002933; Peptidase_M20.
 IPR011650; Peptidase_M20_dimer. 

Pfam

 PF07687; M20_dimer
 PF01546; Peptidase_M20 

SMART

  

PROSITE

 PS00758; ARGE_DAPE_CPG2_1
 PS00759; ARGE_DAPE_CPG2_2 

PRINTS