CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009382
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glucose-1-phosphate thymidylyltransferase 2 
Protein Synonyms/Alias
 G1P-TT 2; dTDP-glucose pyrophosphorylase 2; dTDP-glucose synthase 2 
Gene Name
 rmlA2 
Gene Synonyms/Alias
 rffH; yifG; b3789; JW3763 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
58IITTPEDKGYFQRLLacetylation[1]
160RAISLEEKPKQPKSNacetylation[1]
267WLDDEGVKRAASSLAacetylation[1]
275RAASSLAKTGYGQYLacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. 
Sequence Annotation
 METAL 108 108 Magnesium.
 METAL 223 223 Magnesium.  
Keyword
 3D-structure; Complete proteome; Exopolysaccharide synthesis; Magnesium; Metal-binding; Nucleotidyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 293 AA 
Protein Sequence
MKGIILAGGS GTRLHPITRG VSKQLLPIYD KPMIYYPLSV LMLAGIREIL IITTPEDKGY 60
FQRLLGDGSE FGIQLEYAEQ PSPDGLAQAF IIGETFLNGE PSCLVLGDNI FFGQGFSPKL 120
RHVAARTEGA TVFGYQVMDP ERFGVVEFDD NFRAISLEEK PKQPKSNWAV TGLYFYDSKV 180
VEYAKQVKPS ERGELEITSI NQMYLEAGNL TVELLGRGFA WLDTGTHDSL IEASTFVQTV 240
EKRQGFKIAC LEEIAWRNGW LDDEGVKRAA SSLAKTGYGQ YLLELLRARP RQY 293 
Gene Ontology
 GO:0008879; F:glucose-1-phosphate thymidylyltransferase activity; IDA:UniProtKB.
 GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
 GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0045226; P:extracellular polysaccharide biosynthetic process; IDA:UniProtKB. 
Interpro
 IPR005907; G1P_thy_trans_s.
 IPR005835; NTP_transferase. 
Pfam
 PF00483; NTP_transferase 
SMART
  
PROSITE
  
PRINTS