UniProt Accession

 ADPPT_MOUSE; Q9CQF6; Q5U5W8; Q9CU40; Q9D827 

Genbank Protein ID

 AK007737; AK008554; AK010557; AK013111; AK018191; AK076099; AK076866; AK144671; BC038013; BC049851 

Genbank Nucleotide ID

 BAB25224.1; BAB25740.1; BAB27026.1; BAB28656.1; BAB31116.1; BAC36182.1; BAC36512.1; BAE26000.1; AAH38013.1; AAH49851.1 

Protein Name

 L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 

Protein Synonyms/Alias

 4'-phosphopantetheinyl transferase; Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase; AASD-PPT 

Gene Name

 Aasdhppt 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
50	EEKERIGKFVFARDA	ubiquitination	[1]
91	LQRTSKGKPVLAKDS	acetylation	[2]
263	VSYQDDSKLSQRKFT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN (in vitro) (By similarity). 

Sequence Annotation

 REGION 86 91 Coenzyme A binding (By similarity).
 REGION 108 111 Coenzyme A binding (By similarity).
 REGION 181 185 Coenzyme A binding (By similarity).
 METAL 129 129 Magnesium (By similarity).
 METAL 181 181 Magnesium (By similarity).
 BINDING 47 47 Coenzyme A (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Magnesium; Metal-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 309 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008897; F:holo-[acyl-carrier-protein] synthase activity; ISS:UniProtKB.
 GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
 GO:0009059; P:macromolecule biosynthetic process; IEA:InterPro. 

Interpro

 IPR008278; 4-PPantetheinyl_Trfase_SF. 

Pfam

 PF01648; ACPS 

SMART

  

PROSITE

  

PRINTS