Tag | Content |
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CPLM ID | CPLM-021398 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Piezo-type mechanosensitive ion channel component 2 |
Protein Synonyms/Alias | Protein FAM38B |
Gene Name | PIEZO2 |
Gene Synonyms/Alias | C18orf30; C18orf58; FAM38B |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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146 | LCRNIVQKPVTDEAA | ubiquitination | [1] | 780 | KLEDLGLKQFTVAEL | ubiquitination | [1] | 1513 | GEGQDMQKLSEEDDE | ubiquitination | [1] | 1632 | DREDEPIKKKSDGPD | ubiquitination | [1] | 1886 | TASELLLKKMFHDDE | ubiquitination | [1] | 2148 | KRELYMEKLQEHLIK | ubiquitination | [1] |
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Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Component of mechanosensitive channel required for rapidly adaptating mechanically activated (MA) currents in DRG neurons (By similarity). |
Sequence Annotation | CARBOHYD 95 95 N-linked (GlcNAc...) (Potential). CARBOHYD 1013 1013 N-linked (GlcNAc...) (Potential). CARBOHYD 1085 1085 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2752 AA |
Protein Sequence | MASEVVCGLI FRLLLPICLA VACAFRYNGL SFVYLIYLLL IPLFSEPTKT TMQGHTGRLL 60 KSLCFISLSF LLLHIIFHIT LVSLEAQHRI APGYNCSTWE KTFRQIGFES LKGADAGNGI 120 RVFVPDIGMF IASLTIWLLC RNIVQKPVTD EAAQSNPEFE NEELAEGEKI DSEEALIYEE 180 DFNGGDGVEG ELEESTKLKM FRRLASVASK LKEFIGNMIT TAGKVVVTIL LGSSGMMLPS 240 LTSSVYFFVF LGLCTWWSWC RTFDPLLFSC LCVLLAIFTA GHLIGLYLYQ FQFFQEAVPP 300 NDYYARLFGI KSVIQTDCSS TWKIIVNPDL SWYHHANPIL LLVMYYTLAT LIRIWLQEPL 360 VQDEGTKEED KALACSPIQI TAGRRRSLWY ATHYPTDERK LLSMTQDDYK PSDGLLVTVN 420 GNPVDYHTIH PSLPMENGPG KADLYSTPQY RWEPSDESSE KREEEEEEKE EFEEERSREE 480 KRSIKVHAMV SVFQFIMKQS YICALIAMMA WSITYHSWLT FVLLIWSCTL WMIRNRRKYA 540 MISSPFMVVY GNLLLILQYI WSFELPEIKK VPGFLEKKEP GELASKILFT ITFWLLLRQH 600 LTEQKALQEK EALLSEVKIG SQENEEKDEE LQDIQVEGEP KEEEEEEAKE EKQERKKVEQ 660 EEAEEEDEQD IMKVLGNLVV AMFIKYWIYV CGGMFFFVSF EGKIVMYKII YMVLFLFCVA 720 LYQVHYEWWR KILKYFWMSV VIYTMLVLIF IYTYQFENFP GLWQNMTGLK KEKLEDLGLK 780 QFTVAELFTR IFIPTSFLLV CILHLHYFHD RFLELTDLKS IPSKEDNTIY RLAHPEGSLP 840 DLTMMHLTAS LEKPEVRKLA EPGEEKLEGY SEKAQKGDLG KDSEESEEDG EEEEESEEEE 900 ETSDLRNKWH LVIDRLTVLF LKFLEYFHKL QVFMWWILEL HIIKIVSSYI IWVSVKEVSL 960 FNYVFLISWA FALPYAKLRR LASSVCTVWT CVIIVCKMLY QLQTIKPENF SVNCSLPNEN 1020 QTNIPFNELN KSLLYSAPID PTEWVGLRKS SPLLVYLRNN LLMLAILAFE VTIYRHQEYY 1080 RGRNNLTAPV SRTIFHDITR LHLDDGLINC AKYFINYFFY KFGLETCFLM SVNVIGQRMD 1140 FYAMIHACWL IAVLYRRRRK AIAEIWPKYC CFLACIITFQ YFICIGIPPA PCRDYPWRFK 1200 GASFNDNIIK WLYFPDFIVR PNPVFLVYDF MLLLCASLQR QIFEDENKAA VRIMAGDNVE 1260 ICMNLDAASF SQHNPVPDFI HCRSYLDMSK VIIFSYLFWF VLTIIFITGT TRISIFCMGY 1320 LVACFYFLLF GGDLLLKPIK SILRYWDWLI AYNVFVITMK NILSIGACGY IGTLVHNSCW 1380 LIQAFSLACT VKGYQMPAAN SPCTLPSGEA GIIWDSICFA FLLLQRRVFM SYYFLHVVAD 1440 IKASQILASR GAELFQATIV KAVKARIEEE KKSMDQLKRQ MDRIKARQQK YKKGKERMLS 1500 LTQEPGEGQD MQKLSEEDDE READKQKAKG KKKQWWRPWV DHASMVRSGD YYLFETDSEE 1560 EEEEELKKED EEPPRRSAFQ FVYQAWITDP KTALRQRHKE KKRSAREERK RRRKGSKEGP 1620 VEWEDREDEP IKKKSDGPDN IIKRIFNILK FTWVLFLATV DSFTTWLNSI SREHIDISTV 1680 LRIERCMLTR EIKKGNVPTR ESIHMYYQNH IMNLSRESGL DTIDEHPGAA SGAQTAHRMD 1740 SLDSHDSISS EPTQCTMLYS RQGTTETIEE VEAEQEEEAG STAPEPREAK EYEATGYDVG 1800 AMGAEEASLT PEEELTQFST LDGDVEAPPS YSKAVSFEHL SFGSQDDSAG KNRMAVSPDD 1860 SRTDKLGSSI LPPLTHELTA SELLLKKMFH DDELEESEKF YVGQPRFLLL FYAMYNTLVA 1920 RSEMVCYFVI ILNHMVSASM ITLLLPILIF LWAMLSVPRP SRRFWMMAIV YTEVAIVVKY 1980 FFQFGFFPWN KNVEVNKDKP YHPPNIIGVE KKEGYVLYDL IQLLALFFHR SILKCHGLWD 2040 EDDMTESGMA REESDDELSL GHGRRDSSDS LKSINLAASV ESVHVTFPEQ QTAVRRKRSG 2100 SSSEPSQRSS FSSNRSQRGS TSTRNSSQKG SSVLSIKQKG KRELYMEKLQ EHLIKAKAFT 2160 IKKTLEIYVP IKQFFYNLIH PEYSAVTDVY VLMFLADTVD FIIIVFGFWA FGKHSAAADI 2220 TSSLSEDQVP GPFLVMVLIQ FGTMVVDRAL YLRKTVLGKV IFQVILVFGI HFWMFFILPG 2280 VTERKFSQNL VAQLWYFVKC VYFGLSAYQI RCGYPTRVLG NFLTKSYNYV NLFLFQGFRL 2340 VPFLTELRAV MDWVWTDTTL SLSSWICVED IYAHIFILKC WRESEKPIFT MSAQQSQLKV 2400 MDQQSFNKFI QAFSRDTGAM QFLENYEKED ITVAELEGNS NSLWTISPPS KQKMIHELLD 2460 PNSSFSVVFS WSIQRNLSLG AKSEIATDKL SFPLKNITRK NIAKMIAGNS TESSKTPVTI 2520 EKIYPYYVKA PSDSNSKPIK QLLSENNFMD ITIILSRDNT TKYNSEWWVL NLTGNRIYNP 2580 NSQALELVVF NDKVSPPSLG FLAGYGIMGL YASVVLVIGK FVREFFSGIS HSIMFEELPN 2640 VDRILKLCTD IFLVRETGEL ELEEDLYAKL IFLYRSPETM IKWTREKTN 2689 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005261; F:cation channel activity; IEA:Compara. GO:0008381; F:mechanically-gated ion channel activity; IEA:Compara. GO:0006812; P:cation transport; ISS:UniProtKB. GO:0042391; P:regulation of membrane potential; IEA:Compara. |
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