| Tag | Content |
|---|
| CPLM ID | CPLM-016579 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Casein kinase I isoform gamma-1 |
Protein Synonyms/Alias | CKI-gamma 1 |
Gene Name | Csnk1g1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 255 | SLPWQGLKADTLKER | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CLSPN (By similarity). Regulates fast synaptic transmission mediated by glutamate. |
Sequence Annotation | DOMAIN 44 315 Protein kinase.
NP_BIND 50 58 ATP (By similarity).
ACT_SITE 164 164 Proton acceptor (By similarity).
BINDING 73 73 ATP (By similarity).
MOD_RES 344 344 Phosphoserine (By similarity). |
Keyword | ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 459 AA |
Protein Sequence | MDHSNREKDD RQRTTKTMAQ RNTHCSRPSG TSTSSGVLMV GPNFRVGKKI GCGNFGELRL 60
GKNLYTNEYV AIKLEPIKSR APQLHLEYRF YKQLGSAGEG LPQVYYFGPC GKYNAMVLEL 120
LGPSLEDLFD LCDRTFTLKT VLMIAIQLLS RMEYVHSKNL IYRDVKPENF LIGRQGNKKE 180
HVIHIIDFGL AKEYVDPETK KHIPYREHKS LTGTARYMSI NTHLGKEQSR RDDLEALGHM 240
FMYFLRGSLP WQGLKADTLK ERYQKIGDTK RNTPIEALCE NFPEEMATYL RYVRRLDFFE 300
KPDYEYLRTL FTDLFERKGY TFDYAYDWVG RPIPTPVGSV HVDSGASAIT RESHTHRDRP 360
SQQQPLRNQT TSSERRGEWE IQPSRQTNTS YLTSHLAADR HGGSVQVVSS TNGELNVDDP 420
TGAHSNAPIT AHAEVEVVEE AKCCCFFKRK RKKTAQRHK 459 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0000287; F:magnesium ion binding; IEA:Compara. GO:0042277; F:peptide binding; IEA:Compara. GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. GO:0046777; P:protein autophosphorylation; IEA:Compara. GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |