CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031763
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 
Protein Synonyms/Alias
  
Gene Name
 TGME49_055180, TGVEG_079210 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Toxoplasma gondii 
NCBI Taxa ID
 5811 
Lysine Modification
Position
Peptide
Type
References
618PGASGIGKKKNENAYacetylation[1]
Reference
 [1] Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii.
 Xue B, Jeffers V, Sullivan WJ, Uversky VN.
 Mol Biosyst. 2013 Apr 5;9(4):645-57. [PMID: 23403842
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4187 AA 
Protein Sequence
MDELGDSVLQ QDAAAPASST FARCDQTATG REPSLSASVL QGSPQRTGVD ISRRWASESP 60
LASSSAATLS LCPVDQIRKT SKRTGSSRGD DRVERSVQES AWTPCSEKSE ASGAAHAGSR 120
SRHSPICSVV FTSPPAAVAP PSKASAASAV SGLCLQPEGS TPERLRVAQG AAPKVSPLED 180
GIPVATVKLA GLETCRTDHP HSPAAPQLAP QHQAPSEELN VSARLHTETR IQANDISVSH 240
ASASGSLPPL PSVAFFLHRA ASTCALASHA SSSDDGSAAR PSVQGICGPE KPNARQTGSS 300
EHELSPSISS TLSVSNSGAL SPRRSRGCTA FGQTGTFISP PTACSSRLSP RGGRQERQLA 360
GTKGELTEME AAFGAETKTE RERVSARGTE RELEFGDKPM EMTQESWRVE SGDVEERDSG 420
VESDLSGDAR QKGEKTAAVA TEVHPMQTDA APRLGGGTRQ LHQEGQHVMS SGECLAGLLW 480
PRDQLSLSVT ASRTARVSST HQKESLGEAR EEKPSGPDTL QPTSKEGFSQ TAQDSEQLSP 540
VHVAPSSLSE QCCLGDLLFM YNLRHSFAVP RESQQDAHPM SVFGLGEFKT GVWGKGGQGG 600
PGGGAGGASG PGASGIGKKK NENAYSLQRE LQQQQMAVRW LLSVTGNGSS ETSATGALPR 660
RSRLARMSPV SKAFGAVSAK HEPAGQAASA LFSGSSSSAS AVTSAPGLPG DQRGPEACES 720
TMKRERAACE DSGGVPSVSS HGRTGWEQKS EQAAILGATG LRKCRYVGLE NLGATCYLNV 780
YLQTLFMNVH FRDFLLSLPT LRELEEMERQ RPAEASRLSL APSTPETHSQ VLARQPREGR 840
TRQYSRGAED KKSQAEESDE TGSRDAETAD GEFPESPEPR CKIEERETHM KQDAEERGRP 900
QVKEESPKES TGARTEKTAL VPKENPPEAE RLDVAPPSAT SSVPEPFTPV FSASSPACLT 960
HGGGRAEAVD QENQADSRAR WCNWREKVKG QDVCTVLCSQ RYSLISSLQT IFAKLQEGIQ 1020
AAVRPSVVAD LLAEDLSYQE DANELQHRLF ELLESELGGR ESPLDFLRVL FGGRSRQTVK 1080
CSHCMYSGNK EEYFFQLNCC HKKSHQSGKH EPGDRNSRNS PEETEASRSP SLPLSSSPFS 1140
PEGDLASQEA DDSRAVTSPK QVAASTSSRC GPCPLSSLPA SQGESLSSSQ EDSTCAPASG 1200
PVDSDVAAVS TSRPEQSESK RHGRRGKRGP QRGAAASAHT GAGGQQGGTQ GTAGGRRREG 1260
RDSCERKGEA SSTSARGPGR KGVSAGQGRR PVDENKGGWK LEEDMARQYQ RTENLRGDSE 1320
YFCPQCGEKR EAKKRSQLSL LPPYLQLVVL RYSIDVKKQT GEWVRRKIHE ALEIPLVMDV 1380
RGCCTDDCQI GHLDGTLSSL RDASHAAHQY HLFGILEHQG ASATSGHYVA ITRDLRERAA 1440
GRSECADAAS VDDSKKTFLA SSLSDGDASA SLSQTTEAAS PLLPQDDGDR VQGCVSVGDW 1500
REAAPLGEGT LPRQLAPSGL EFLGSPRVCP GRGGEGGAQK VKACALPAEG ERRSDEDRRR 1560
SNADRICYAG GPEGKDACGK EAEGPSFSVD SPQQAPGKLV PAKGFEGDEG RDVTIASSTV 1620
ERDLSSQSVS PPRRGTSASR RKGSLREGYG SPPFLEPTKG FPGVATAAVL LGDADATTSP 1680
ITRDRDAFVF RDPSPFASPR PRWSAPLNGP NETAPEPNSV TVVVDVDASS PSLTVSAGSS 1740
SCSSGLASFP HRSLTPRLCS FPHPSTSVEK TVDKDYLRSG FAAATDACSA ETSSAPGPGA 1800
LPNFPTHASP SSSILSCGLN SSPADSSTSP SLKPYDGAGE TTNEDACVEV CEEPFLTHTP 1860
QAEKSRGRSQ AEALDASTLS PTTVTQKDLF SLEFKSPRSR HAALGRLSTW VAAPEPNAVE 1920
ARESGRGDRK RVEALEAQKG SCGPKKKGNA SLTQRTLDQY VGRTRAQVRG RDTGCTARKG 1980
GSSPCVSTAS PPRLASSPPG GAATCWSRES PDKKRRKREA ERGREEQTKR KADQLQRCTG 2040
RDCTQAVGDR QSRSGGKKEK QGGENSVSLV VVETPEEEDD DTDVEEEFVI LASPFQHEAS 2100
RQSAHETRHE NGSSQVAEAD EFYQGKEPQM KTALNKLTTR SLAVDDDLEE IPEVILGAGL 2160
PAEKKQPFGV QPEPSDNADK GRSTSDVVET KAAPQTAATR WSWVRFDDSE EGEWRRATPE 2220
AERVGATSRA PVGRSFSAGP LRIYSRTVYM VTYIRADLTA EETDMPLPRE LQDFIDEEVS 2280
ARTGREGEAG QRAALDENER AKERLTKNER ICEEQETLSM RQQTLLAYVQ QRQAALQQLL 2340
RHALPSALKE LEQQRLERVQ KEALHGEVVR ARLPSPVCER NLVNIQQRLS LLPQLRQLSF 2400
IPRSWWQQFV RGIDYPTMST SLPPSLLPRR DSNNRNGICM VPLTKAENGD GNRPARKRKK 2460
NNAEQRGAAG SSREKSEDEL RERGRLGAPG EEHATAGESE LEGSANAGAK KEAKEEDLRG 2520
LSICEVLEGE TREGRQQSRS AMKSEEAAIS GHRQQWLQTS GGGRDAYSRA ANAQEEVKAY 2580
RQLEQSYADG GTTSEETREG RDGDATSPAC RSENDKEKGV IDYSSILCPH YRNALAASIS 2640
CSPAAAGTVV SPQDALVTSS LSMPALPLNA SSFHEAHRPW IFNSISEPDE EKLLAEPSYP 2700
IEKLLRVTDF CGERGVDPLS IWTGEAKAIP TALFSDLLAA SALRPSIPDP SLLPNLCSVC 2760
SAALSGLVDF YSEQHRSIEA ILEALKRQKT IPTVCEETPV SPELVESSSA CAIPSSTANL 2820
SSPPKEVTVS STANGEADRA EGVHLQFVHA GGDGDTAPAR SESSQETEKN QEETIHAEVL 2880
PSIVVPLPSP DDVHLRSSSQ EPSASSVAPG DQQQGGEKEE TQGGRQISCV ASPCGVGALS 2940
PIVCAGVDEV PDSSKVAPVQ DAEGNRQVSV SSSQSRVEGS GPDSGDNQRL ETEEPLSPRI 3000
LNEHETPATD LLGCCIPSAS LSSSPRAAVP ALNPWVLEHT ATLPEFIYVS RRPLQRAFSL 3060
HSCFLTLCTL PTASSPASIP FSALLPSSSS PQSRELKVLR AKMKREGKDS REKYLSWLTL 3120
SDVRREVTLG RKLPQGDSDP SRGVKPPKKD ARKDGDWERA EEGIEEGEAS DGDGTNDGRR 3180
RRRKKVEDEE QGEEQVCGDE DVEDVNMDDE GEESASLGSL LHAEDEGNAT KKTRVTRARK 3240
AVSSPPGANR KAVAHTLHRA TSRPRSDHKQ EENEDLEEEE GNTEEGQGNS QDAHTGRDNV 3300
FDFASDLLCC HQKLRIQGAV GKSNKLQRFL VNKVPTAAIL NFLYFEREKA VLYRELGIAN 3360
PVTFDCSTFV SQYAQECSIC LTEQQAEQQR RQVWRDKRNE ESKALGQIIG KRWRLRKETG 3420
PASRLATPLP KKGRFFFVST EWRHQWLSYV ASGCETEGVT SKPPPLLNSS LLCDCPTRGL 3480
KVDPTDTLLS PTFLADPPES ETDTYILVHE DDVDLLERFG LTGFKTAENL SMCVEVKHIP 3540
GEIASSLLPP SSSPSSRLAA SPCFAGPVPA FFFPSLAPCS ACVRTHRIEQ GFYDFPPVDL 3600
SFHLRQNRWN GDAPEVKSEP ETVREAGPGR GRGNTGNGGR RQASSRVLGQ KKITVRVSGE 3660
TEIASLLAHV VASMTEAEET KETTVYLEGP PRHVFYFSPK SSCLSVSIPD AGPTASPPNR 3720
SVYPSTSPTT TDTLPRTAPS LICNAAAAHS PPAAPRRYSG HREEGKDTQL LGDLCDGRAV 3780
TRPLCLSPSG ARQKERHENR EACDVLCLER TERATTENEA EPRGERESQS QAEISTRPLV 3840
SFVDEEVGKA VKADASGTRV RLPEETYTGS EHSGITLRAV SLPHSCCLSL EVEMKTHLRD 3900
LLLYVNEAWQ VSYEFQESRQ LDEVRREKAV RKEAEAATED EAALVSVALQ EGGFLEAEEG 3960
TRRRQADREA TERVLEIQDS EKEDDGGSAG EASQVEECVE VQDASTSAEK LARKPLSPLP 4020
GDSLVRNKRE RSEEPEPVDV LTDGEEQEEL AQSDQKKSRF ATTHPTSQGL CSLLRGDGKC 4080
DNGTENRRKT AGRNMPARRS DNLTQERELR RPQDTRAGRN QRGNRQHASL LEDPGPKTGV 4140
PGQPDTTGCF IHQQLHSSTG NMRQDRTPTE TIVLLDDDED DRAAPSR 4187 
Gene Ontology
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19. 
Pfam
 PF00443; UCH 
SMART
  
PROSITE
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS