| Tag | Content |
|---|
| CPLM ID | CPLM-019183 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Elongator complex protein 4 |
Protein Synonyms/Alias | hELP4; PAX6 neighbor gene protein |
Gene Name | ELP4 |
Gene Synonyms/Alias | C11orf19; PAXNEB |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 188 | GHYYDASKRMPQELI | ubiquitination | [1] | | 214 | EKISSTLKVEPCSLT | ubiquitination | [1] | | 367 | ICDESDVKDLAFKLK | ubiquitination | [1] | | 376 | LAFKLKRKLFTIERL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. |
Sequence Annotation | |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 424 AA |
Protein Sequence | MAAVATCGSV AASTGSAVAT ASKSNVTSFQ RRGPRASVTN DSGPRLVSIA GTRPSVRNGQ 60
LLVSTGLPAL DQLLGGGLAV GTVLLIEEDK YNIYSPLLFK YFLAEGIVNG HTLLVASAKE 120
DPANILQELP APLLDDKCKK EFDEDVYNHK TPESNIKMKI AWRYQLLPKM EIGPVSSSRF 180
GHYYDASKRM PQELIEASNW HGFFLPEKIS STLKVEPCSL TPGYTKLLQF IQNIIYEEGF 240
DGSNPQKKQR NILRIGIQNL GSPLWGDDIC CAENGGNSHS LTKFLYVLRG LLRTSLSACI 300
ITMPTHLIQN KAIIARVTTL SDVVVGLESF IGSERETNPL YKDYHGLIHI RQIPRLNNLI 360
CDESDVKDLA FKLKRKLFTI ERLHLPPDLS DTVSRSSKMD LAESAKRLGP GCGMMAGGKK 420
HLDF 424 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0016591; C:DNA-directed RNA polymerase II, holoenzyme; IDA:HGNC. GO:0033588; C:Elongator holoenzyme complex; IDA:UniProtKB. GO:0008023; C:transcription elongation factor complex; IDA:UniProtKB. GO:0008607; F:phosphorylase kinase regulator activity; IDA:UniProtKB. GO:0016573; P:histone acetylation; IDA:GOC. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB. GO:0006368; P:transcription elongation from RNA polymerase II promoter; IC:HGNC. |
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Pfam | |
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PRINTS | |