CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013760
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aspartoacylase-2 
Protein Synonyms/Alias
 Aminoacylase-3; ACY-3 
Gene Name
 Acy3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
297EKRVAFLKSEKIRISacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity). 
Sequence Annotation
 REGION 70 71 Substrate binding (Potential).
 METAL 21 21 Zinc (Potential).
 METAL 24 24 Zinc (Potential).
 METAL 116 116 Zinc (Potential).
 BINDING 63 63 Substrate (Potential).
 BINDING 178 178 Substrate (Potential).
 BINDING 288 288 Substrate (Potential).  
Keyword
 Cell membrane; Complete proteome; Cytoplasm; Hydrolase; Membrane; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 319 AA 
Protein Sequence
MCSLPGSRKP LLRVAVTGGT HGNEMCGVYL ARYWLQNPGE LQRPSFSAMP VLANPAATAA 60
CRRYIDRDLN RTFTLTFLGS TATPDDPYEV KRAQELNQLL GPKGTCQAFD FILDLHNTTA 120
NTGACLISEV SQNPFNLHLC HYLQLQNPGL PCRLFQFEPP GTESYSMDSV SKNGISLELG 180
PQPQGVLRAE LFSQMRAMVA SILDFIELFN QGMEFPAFEM EVYKNLGSVD FPRTTDGHLT 240
GTVHSRLQDH DFEPLRPGEP IFKLFSGEDV LYEGDSVVYP LFVNEAAYYE KRVAFLKSEK 300
IRISVPALPG LTPSSTQTP 319 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004046; F:aminoacylase activity; IEA:Compara.
 GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 
Interpro
 IPR016708; Aspartoacylase.
 IPR007036; Aste_AspA. 
Pfam
 PF04952; AstE_AspA 
SMART
  
PROSITE
  
PRINTS