| Tag | Content |
|---|
| CPLM ID | CPLM-014394 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | P protein |
Protein Synonyms/Alias | Melanocyte-specific transporter protein; Pink-eyed dilution protein |
Gene Name | Oca2 |
Gene Synonyms/Alias | P |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 573 | VRGLLLEKVLALEHL | acetylation | [1] |
|
Reference | [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [ PMID: 23576753] |
Functional Description | Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the postranslational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. It can modulate intracellular glutathione metabolism. |
Sequence Annotation | MOD_RES 157 157 Phosphoserine.
CARBOHYD 210 210 N-linked (GlcNAc...) (Potential).
CARBOHYD 214 214 N-linked (GlcNAc...) (Potential).
CARBOHYD 269 269 N-linked (GlcNAc...) (Potential). |
Keyword | Albinism; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 833 AA |
Protein Sequence | MRLENKDIRL ASAVLEVELH QTSALSVPTC PDPGRLLTVK PATSNYKLGQ ADPCIPYAGE 60
AAGKSVCVPE HTEFGSFLVK GSSSLKDLSF KEDTPLLWNS SQKKRSQLMP VHHPEFIATE 120
GSWENGLTAW EQKCMLGKEV ADLSALASSE KRDLAGSVHL RAQVSKLGCC VRWIKITGLF 180
VFVVLCSILF SLYPDQGKFW QLLAVSPLEN YSVNLSGHAD SMILQLDLAG ALMAGGPSGS 240
GKEEHVVVVV TQTDAAGNRR RRPQQLTYNW TVLLNPRSEH VVVSRTFEIV SREAVSISIQ 300
ASLQQTRLVP LLLAHQFLGA SVEAQVASAV AILAGVYTLI IFEIVHRTLA AMLGALAALA 360
ALAVVGDRPS LTHVVEWIDF ETLALLFGMM ILVAVFSETG FFDYCAVKAY QLSRGRVWAM 420
IFMLCLMAAI LSAFLDNVTT MLLFTPVTIR LCEVLNLDPR QVLIAEVIFT NIGGAATAIG 480
DPPNVIIVSN QELRKMGLDF AGFTAHMFLG ICLVLLVSFP LLRLLYWNKK LYNKEPSEIV 540
ELKHEIHVWR LTAQRISPAS REETAVRGLL LEKVLALEHL LAQRLHTFHR QISQEDKNWE 600
TNIQELQRKH RISDRSLLVK CLTVLGFVIS MFFLNSFVPG IHLDLGWIAI LGAIWLLILA 660
DIHDFEIILH RVEWATLLFF AALFVLMEAL THLHLVEYVG EQTALLIKMV PEDQRFAAAI 720
VLIVWVSALA SSLIDNIPFT ATMIPVLLNL SQDPEISLPA LPLMYALALG ACLGGNGTLI 780
GASTNVVCAG IAEKHGYGFS FMEFFRLGFP VMLMSCTIGM CYLLIAHIVV GWN 833 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:Compara. GO:0010008; C:endosome membrane; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005765; C:lysosomal membrane; IEA:Compara. GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell. GO:0008283; P:cell proliferation; IMP:MGI. GO:0042438; P:melanin biosynthetic process; IMP:MGI. GO:0030318; P:melanocyte differentiation; IMP:MGI. GO:0007286; P:spermatid development; IMP:MGI. GO:0055085; P:transmembrane transport; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |