| Tag | Content |
|---|
| CPLM ID | CPLM-016723 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | F-box/LRR-repeat protein 3 |
Protein Synonyms/Alias | F-box and leucine-rich repeat protein 3A; F-box/LRR-repeat protein 3A; Protein after-hours; Protein overtime |
Gene Name | Fbxl3 |
Gene Synonyms/Alias | Afh; Fbl3a; Fbxl3a; Ovtm |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 201 | ANNSDTLKLLKMSSC | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. FBXL3 probably recognizes and binds phosphorylated CRY1 and CRY2. |
Sequence Annotation | DOMAIN 34 81 F-box.
REPEAT 119 146 LRR 1.
REPEAT 181 207 LRR 2.
REPEAT 208 233 LRR 3.
REPEAT 234 259 LRR 4.
REPEAT 316 341 LRR 5.
REPEAT 343 368 LRR 6.
REPEAT 369 394 LRR 7. |
Keyword | Alternative splicing; Biological rhythms; Complete proteome; Cytoplasm; Leucine-rich repeat; Nucleus; Reference proteome; Repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 428 AA |
Protein Sequence | MKRGGRDSDQ DSAEEGTAEK PKRPRTTQER SQPCDWGNLL QDIVLHVFKY LPLLDRAHAS 60
QVCRNWNQVF HMPDLWRCFE FELNQPATSY LKATHPELIK QIIKRHSNHL QYVSFKVDSS 120
KESAEAACDI LSQLVNCSLK TLGLISTARP SFMDLPKSHF ISALTVVFVN SKSLSSLKID 180
DTPVDDPSLK VLVANNSDTL KLLKMSSCPH VSPAGILCVA DQCHGLRELA LNYHLLSDEL 240
LLALSSEKHV RLEHLRIDVV SENPGQTHFH TIQKSSWDAF IKHSPKVNLV MYFFLYEEEF 300
DPFFRYEIPA THLYFGRSVS KDVLGRVGMT CPRLVELVVC ANGLRPLDEE LIRIAERCKN 360
LSAIGLGECE VSCSAFVEFV KMCGGRLSQL SIMEEVLIPD QKYSLEQIHW EVSKHLGRVW 420
FPDMMPTW 428 |
Gene Ontology | GO:0005829; C:cytosol; IDA:UniProtKB. GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB. GO:0004842; F:ubiquitin-protein ligase activity; IEA:Compara. GO:0043153; P:entrainment of circadian clock by photoperiod; IMP:UniProtKB. GO:0016567; P:protein ubiquitination; IDA:UniProtKB. GO:0048511; P:rhythmic process; IEA:UniProtKB-KW. GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB. |
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