| Tag | Content |
|---|
| CPLM ID | CPLM-012670 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Gamma-aminobutyric acid receptor subunit alpha-6 |
Protein Synonyms/Alias | GABA(A) receptor subunit alpha-6 |
Gene Name | GABRA6 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 181 | FGSYAYPKSEIIYTW | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
Sequence Annotation | CARBOHYD 31 31 N-linked (GlcNAc...) (Potential).
CARBOHYD 128 128 N-linked (GlcNAc...) (Potential).
CARBOHYD 141 141 N-linked (GlcNAc...) (Potential).
DISULFID 156 170 By similarity. |
Keyword | Cell junction; Cell membrane; Chloride; Chloride channel; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Polymorphism; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 453 AA |
Protein Sequence | MASSLPWLCI ILWLENALGK LEVEGNFYSE NVSRILDNLL EGYDNRLRPG FGGAVTEVKT 60
DIYVTSFGPV SDVEMEYTMD VFFRQTWTDE RLKFGGPTEI LSLNNLMVSK IWTPDTFFRN 120
GKKSIAHNMT TPNKLFRIMQ NGTILYTMRL TINADCPMRL VNFPMDGHAC PLKFGSYAYP 180
KSEIIYTWKK GPLYSVEVPE ESSSLLQYDL IGQTVSSETI KSNTGEYVIM TVYFHLQRKM 240
GYFMIQIYTP CIMTVILSQV SFWINKESVP ARTVFGITTV LTMTTLSISA RHSLPKVSYA 300
TAMDWFIAVC FAFVFSALIE FAAVNYFTNL QTQKAKRKAQ FAAPPTVTIS KATEPLEAEI 360
VLHPDSKYHL KKRITSLSLP IVSSSEANKV LTRAPILQST PVTPPPLSPA FGGTSKIDQY 420
SRILFPVAFA GFNLVYWVVY LSKDTMEVSS SVE 453 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. GO:0008503; F:benzodiazepine receptor activity; TAS:ProtInc. GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW. GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro. GO:0004890; F:GABA-A receptor activity; IEA:InterPro. GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro. GO:0034220; P:ion transmembrane transport; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |