CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032799
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mediator complex subunit MED24 variant MED24_i2 
Protein Synonyms/Alias
 Mediator of RNA polymerase II transcription subunit 24 
Gene Name
 MED24 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
116LDDVQPSKLMRLLSSubiquitination[1, 2, 3]
268VSAMSSPKVVLAITDubiquitination[3]
287LGRQVAAKAIAAL**ubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 292 AA 
Protein Sequence
VYWFCNNLIK ELLKETRKEH TLRAVELLYS IFCLDMQQVT LVLLGHILPG LLTDSSKWHS 60
LMDPPGTALA KLAVWCALSS YSSHKGQAST RQKKRHREDI EDYISLFPLD DVQPSKLMRL 120
LSSNEDDANI LSSPRSSLGS PCTSYLRWVK VGLGHPRGAP LLHSAGCFPA LHLLRPTADR 180
SMSSSLSASQ LHTVNMRDPL NRVLANLFLL ISSILGSRTA GPHTQFVQWF MEECVDCLEQ 240
GGRGSVLQFM PFTTVSELVK VSAMSSPKVV LAITDLSLPL GRQVAAKAIA AL 292 
Gene Ontology
  
Interpro
 IPR021429; Mediator_Med24_N. 
Pfam
 PF11277; Med24_N 
SMART
  
PROSITE
  
PRINTS