UniProt Accession

 RIP_HUMAN; Q86UA6; B4DI36; B4DTX7; E9PES3; J3KNH8; Q4G2Y0; Q4G2Y5; Q4G2Y8; Q6B4V9; Q6B4W0; Q6B4W1; Q6B4W4; Q86X49; Q9BT00 

Genbank Protein ID

 AY775314; AY775315; AY775316; AY775317; AY775318; AY775319; AY775320; AY775321; AY775323; AY680654; AY680655; AY680656; AY680657; AY680658; AY680659; AY680660; AK295394; AK300409; AC004148; BC004451; BC046349; BC051849 

Genbank Nucleotide ID

 AAX14368.1; AAX14369.1; AAX14370.1; AAX14371.1; AAX14372.1; AAX14373.1; AAX14374.1; AAX14375.1; AAX14377.1; AAT80872.1; AAT80873.1; AAT80874.1; AAT80875.1; AAT80876.1; AAT80877.1; AAT80878.1; BAG58348.1; BAG62139.1; AAH04451.1; AAH46349.1; AAH51849.1 

Protein Name

 RPA-interacting protein 

Protein Synonyms/Alias

 hRIP 

Gene Name

 RPAIN 

Gene Synonyms/Alias

 RIP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
14	SPRRSLYKLVGSPPW	ubiquitination	[1, 2, 3]
22	LVGSPPWKEAFRQRC	ubiquitination	[1, 2, 3]
171	SSELTEQKLRACLEG	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism. 

Sequence Annotation

 ZN_FING 137 212 RIP-type.
 REGION 164 180 Mediates nuclear export.
 CROSSLNK 103 103 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 121 121 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Isopeptide bond; Metal-binding; Nucleus; Polymorphism; Reference proteome; Ubl conjugation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 219 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0016605; C:PML body; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006310; P:DNA recombination; IPI:MGI.
 GO:0006281; P:DNA repair; IPI:MGI.
 GO:0006261; P:DNA-dependent DNA replication; IPI:MGI.
 GO:0006606; P:protein import into nucleus; IDA:MGI.
 GO:0009411; P:response to UV; IDA:MGI. 

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PRINTS