| Tag | Content |
|---|
| CPLM ID | CPLM-007902 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vacuolar amino acid transporter 1 |
Protein Synonyms/Alias | |
Gene Name | AVT1 |
Gene Synonyms/Alias | YJR001W; J1409; YJR83.4 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 93 | DNERSFFKESNDETY | ubiquitination | [1] | | 191 | DMDSIVVKRVEGVDG | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Required for the vacuolar uptake of large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine. Requires ATP for function. |
Sequence Annotation | MOD_RES 8 8 Phosphoserine.
MOD_RES 15 15 Phosphoserine.
MOD_RES 35 35 Phosphoserine.
MOD_RES 181 181 Phosphothreonine.
MOD_RES 187 187 Phosphoserine. |
Keyword | Amino-acid transport; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport; Vacuole. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 602 AA |
Protein Sequence | MPEQEPLSPN GRKRSEVHYI SIPLNRGSAF SPDDSVSQFQ SDGFMTRRQS ILDHPVGSFK 60
GVNSLSRFAT SLRRANSFRN IELNADNERS FFKESNDETY DPDTLAPALD GRRLSVTLNN 120
AGRPRITNLA NNDRVSTASM AIHDDDYGSI QNSTIGDSGS ILRPTASLTE MMSGGAGRRF 180
TNNDMDSIVV KRVEGVDGKV VTLLAGQSTA PQTIFNSINV LIGIGLLALP LGLKYAGWVI 240
GLTMLAIFAL ATFCTAELLS RCLDTDPTLI SYADLGYAAF GTKGRALISA LFTLDLLGSG 300
VSLVILFGDS LNALFPQYST TFFKIVSFFI VTPPVFIPLS VLSNISLLGI LSTTGTVLVI 360
CCCGLYKSSS PGSLVNPMET SMWPIDLKHL CLSIGLLSAC WGGHAVFPNL KTDMRHPDKF 420
KDCLKTTYKI TSVTDIGTAV IGFLMFGNLV KDEITKNVLL TEGYPKFVYG LISALMTIIP 480
IAKTPLNARP IVSVLDVLMN VQHIDEAASA IKRRAAKGLQ VFNRIFINVV FVLIAINFPE 540
FDKIIAFLGA GLCFTICLIL PCWFYLRLCK TTIKPWERVA CHVTICISVV LSTLGVGAAI 600
IS 602 |
Gene Ontology | GO:0000329; C:fungal-type vacuole membrane; IMP:SGD. GO:0016021; C:integral to membrane; ISM:SGD. GO:0015186; F:L-glutamine transmembrane transporter activity; IMP:SGD. GO:0015188; F:L-isoleucine transmembrane transporter activity; IMP:SGD. GO:0005302; F:L-tyrosine transmembrane transporter activity; IMP:SGD. GO:0007034; P:vacuolar transport; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |