CPLM-009558

Genbank Nucleotide ID

Protein Synonyms/Alias

Osteogenic growth peptide; OGP

Hist1h4b; Hist1h4m; Hist4h4

Rattus norvegicus (Rat)

Position	Peptide	Type	References
6	**MSGRGKGGKGLGK	acetylation	[1, 2, 3]
9	SGRGKGGKGLGKGGA	acetylation	[1, 2, 3]
13	KGGKGLGKGGAKRHR	acetylation	[1, 2, 3]
17	GLGKGGAKRHRKVLR	acetylation	[1, 2, 3]
32	DNIQGITKPAIRRLA	acetylation	[3]
60	EETRGVLKVFLENVI	acetylation	[3]
78	VTYTEHAKRKTVTAM	acetylation	[3]
80	YTEHAKRKTVTAMDV	acetylation	[3]
92	MDVVYALKRQGRTLY	acetylation	[3]

[1] Sites of "in vitro" enzymatic acetylation of histone H3.
Thwaits BH, Brandt WF, von Holt C.
FEBS Lett. 1976 Dec 1;71(2):193-6. [PMID: 1001435]
[2] Chemically induced gene expression. Manipulation of the transforming ability of simian virus 40 minichromatin by specific chemical hyperacetylation of histones H3 and H4.
Cohen BN, Blue WT, Wagner TE.
Eur J Biochem. 1980 Jun;107(2):511-8. [PMID: 6249595]
[3] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]

Functional Description

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

DNA_BIND 17 21
MOD_RES 2 2 N-acetylserine.
MOD_RES 2 2 Phosphoserine (By similarity).
MOD_RES 4 4 Asymmetric dimethylarginine; by PRMT1;
MOD_RES 4 4 Citrulline; alternate (By similarity).
MOD_RES 4 4 Omega-N-methylarginine; by PRMT1;
MOD_RES 4 4 Symmetric dimethylarginine; by PRMT5 and
MOD_RES 6 6 N6-acetyllysine; alternate (By
MOD_RES 6 6 N6-crotonyl-L-lysine; alternate (By
MOD_RES 9 9 N6-acetyllysine; alternate (By
MOD_RES 9 9 N6-crotonyl-L-lysine; alternate (By
MOD_RES 13 13 N6-acetyllysine; alternate (By
MOD_RES 13 13 N6-crotonyl-L-lysine; alternate (By
MOD_RES 17 17 N6-acetyllysine; alternate.
MOD_RES 17 17 N6-crotonyl-L-lysine; alternate (By
MOD_RES 21 21 N6,N6,N6-trimethyllysine; alternate (By
MOD_RES 21 21 N6,N6-dimethyllysine; alternate.
MOD_RES 21 21 N6-methyllysine; alternate.
MOD_RES 32 32 N6-acetyllysine (By similarity).
MOD_RES 48 48 Phosphoserine; alternate.
MOD_RES 48 48 Phosphoserine; by PAK2; alternate (By
MOD_RES 52 52 Phosphotyrosine (By similarity).
MOD_RES 89 89 Phosphotyrosine (By similarity).
MOD_RES 92 92 N6-acetyllysine; alternate (By
CROSSLNK 92 92 Glycyl lysine isopeptide (Lys-Gly)

Acetylation; Alternative initiation; Chromosome; Citrullination; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; DNA-binding; Isopeptide bond; Methylation; Nucleosome core; Nucleus; Osteogenesis; Phosphoprotein; Reference proteome; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; TAS:RGD.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
GO:0006334; P:nucleosome assembly; IEA:InterPro.
GO:0001503; P:ossification; IEA:UniProtKB-KW.

IPR009072; Histone-fold.
IPR007125; Histone_core_D.
IPR001951; Histone_H4.
IPR019809; Histone_H4_CS.