CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025391
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative uncharacterized protein 
Protein Synonyms/Alias
  
Gene Name
 Sptbn2 
Gene Synonyms/Alias
 Spnb3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
105LSGETLPKPTKGRMRubiquitination[1]
108ETLPKPTKGRMRIHCubiquitination[1]
127DKALQFLKEQKVHLEubiquitination[1]
920DIAEQLLKASPPGKDubiquitination[1]
979AWMREKTKVIESTQGubiquitination[1]
1213AADAAIKKLEDFMSTubiquitination[1]
1437REMAVREKEVEAIQAubiquitination[1]
1868DDGQRLQKAYAGDKAubiquitination[1]
1909LLLDTTDKFRFFKAVubiquitination[1]
2074ERFSALEKLTALEERubiquitination[1]
2304KLGLQDGKEYLFQAKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2388 AA 
Protein Sequence
MSSTLSPTDF DSLEIQGQYS DINNRWDLPD SDWDNDSSSA RLFERSRIKA LADEREAVQK 60
KTFTKWVNSH LARVTCRVGD LYSDLRDGRN LLRLLEVLSG ETLPKPTKGR MRIHCLENVD 120
KALQFLKEQK VHLENMGSHD IVDGNHRLTL GLVWTIILRF QIQDISVETE DNKEKKSAKD 180
ALLLWCQMKT AGYPNVNVHN FTTSWRDGLA FNAIVHKHRP DLLDFESLKK CNAHYNLQNA 240
FNLAEKELGL TKLLDPEDVN VDQPDEKSII TYVATYYHYF SKMKALAVEG KRIGKVLDHA 300
MEAEHLVEKY ESLASELLQW IEQTIVTLND RQLANSLSGV QNQLQSFNSY RTVEKPPKFT 360
EKGNLEVLLF TIQSKLRANN QKVYTPREGR LISDINKAWE RLEKAEHERE LALRTELIRQ 420
EKLEQLAARF DRKAAMRETW LSENQRLVSQ DNFGLELAAV EAAVRKHEAI ETDIVAYSGR 480
VQAVDAVAAE LAAEHYHDIK RIAARQNNVA RLWDFLRQMV AARRERLLLN LELQKVFQDL 540
LYLMDWMAEM KGRLQSQDLG KHLAGVEDLL QLHELVEADI AVQAERVRAV SASALRFCDP 600
GKEYRPCDPQ LVSERVATLE QSYEALCELA ATRRARLEES RRLWRFLWEV GEAEAWVREQ 660
QHLLASADTG RDLTGVLRLL NKHAALRGEM SGRLGPLKLT LEQGQQLVAE GHPGANQAST 720
RAAELQAQWE RLEALAEERA QQLAQAASLY QFQADANDME AWLVDALRLV SSPEVGHDEF 780
STQALARQHR ALEEEIRAHR PTLDALREQA AALPPALSHT PEVQGRVPTL EQHYEELQAR 840
AGERARALEA ALAFYTMLSE AGACGLWVEE KEQWLNGLAL PERLEDLEVV QQRFETLEPE 900
MNALAARVTA VNDIAEQLLK ASPPGKDRII GTQEQLNQRW QQFRSLADGK KAALTSALSI 960
QNYHLECTET QAWMREKTKV IESTQGLGND LAGVLALQRK LAGTDRDLEP ISARVGELTQ 1020
EANALAAGHP AQAPAINTRL GEVQAGWEDL RATMRRREES LGEARRLQDF LRSLDDFQAW 1080
LGRTQTAVAS EEGPATLPEA EALLAQHAAL RGEVERAQSE YSRLRTLGEE VTRDQADPQC 1140
LFLRQRLEAL GTGWEELGRM WESRQGRLAQ AHGFQGFLRD ARQAEGVLSS QEYVLSHTEM 1200
PGTLQAADAA IKKLEDFMST MDANGERIRG LLEAGRQLVS KGNIHAEKIQ EKADSIEKRH 1260
RKNQEAVQQL LGRLRDNREQ QHFLQDCQEL RLWIDEKMLT AQDVSYDEAR NLHTKWQKHQ 1320
AFMAELAANK DWLDKVDKEG RELTLEKPEL KVVVSEKLED LHRRWDELET TTQAKARSLF 1380
DANRAELFAQ SCSALESWLE SLQAQLHSDD YGKDLTSVNI LLKKQQMLER EMAVREKEVE 1440
AIQAQAQALA QEDQSAGEVE RTSRAVEEKF RALCQPMKER CRRLHASREQ HQFHRDVEDE 1500
ILWVTERLPM ASSLEHGKDL PSVQLLMKKN QTLQKEIQGH EPRIADLKER QRTLGTAAAG 1560
PELAELQEMW KRLSHELELR GKRLEEALRA QQFYRDAAEA EAWMGEQELH MMGQEKAKDE 1620
LSAQAEVKKH QVLEQALADY AQTIKQLAAS SQDMIDHEHP ESTRLTIRQA QVDKLYASLK 1680
ELAGERRERL QEHLRLCQLR RELDDLEQWI QEREVVAASH ELGQDYEHVT MLRDKFREFS 1740
KDTSTIGQER VDSANALANG LIAGGHAARA TVAEWKDSLN EAWADLLELL DTRGQVLAAA 1800
YELQRFLHGA RQALARVQHK QQQLPDGTGR DLNAAEALQR RHCAYEHDIQ ALSTQVQQVQ 1860
DDGQRLQKAY AGDKAEEIGR HMQAVAEAWA QLQGSSAARR QLLLDTTDKF RFFKAVRELM 1920
LWMDGINLQM DAQERPRDVS SADLVIKNQQ GIKAEIEARA DRFSSCIDMG QELLARSHYA 1980
AEEISEKLSQ LQSRRQETAD KWQEKMDWLQ LVLEVLVFGR DAGMAEAWLC SQEPLVRSAE 2040
LGCTVDEVES LIKRHEAFQK SAVAWEERFS ALEKLTALEE RENERKRKRE EEERRKQPPT 2100
SEPMASQPEG SLVDGQRVPD TAWDGTQSKL PPSTQAPSVN GVCTDTDSSQ PLLEQQRLEQ 2160
SNVPEGPGSG TGDESSGPRG ERQTLPRGPA PSPMPQSRSS EAAHGATLPT RGPELSAQEQ 2220
MEGMLCRKQE MEAFNKKAAN RSWQNVYCVL RRGSLGFYKD ARAASAGVPY HGEVPVSLAR 2280
AQGSVAFDYR KRKHVFKLGL QDGKEYLFQA KDEAEMSSWL RVVNAAIATA SSAPGESEEP 2340
VVPSASRGLT RAMTMPPVSQ PEGSIVLRSK DGREREREKR FSFFKKNK 2388 
Gene Ontology
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0008091; C:spectrin; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
 GO:0030534; P:adult behavior; IMP:MGI.
 GO:0021692; P:cerebellar Purkinje cell layer morphogenesis; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0007416; P:synapse assembly; IMP:MGI. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR001605; PH_dom-spectrin-type.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR018159; Spectrin/alpha-actinin.
 IPR016343; Spectrin_bsu.
 IPR002017; Spectrin_repeat. 
Pfam
 PF00307; CH
 PF00169; PH
 PF00435; Spectrin 
SMART
 SM00033; CH
 SM00233; PH
 SM00150; SPEC 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS50003; PH_DOMAIN 
PRINTS
 PR00683; SPECTRINPH.