| Tag | Content |
|---|
| CPLM ID | CPLM-026164 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Inosine-5'-monophosphate dehydrogenase |
Protein Synonyms/Alias | IMP dehydrogenase; IMPD; IMPDH |
Gene Name | guaB |
Gene Synonyms/Alias | TTHA0432 |
Created Date | July 27, 2013 |
Organism | Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) |
NCBI Taxa ID | 300852 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 411 | RYFQDPEKGETEAKK | acetylation | [1] |
|
Reference | [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus. Okanishi H, Kim K, Masui R, Kuramitsu S. J Proteome Res. 2013 Aug 1;. [ PMID: 23901841] |
Functional Description | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity). |
Sequence Annotation | DOMAIN 95 153 CBS 1 (By similarity).
DOMAIN 155 213 CBS 2 (By similarity).
NP_BIND 301 303 NAD (By similarity).
REGION 341 343 IMP binding (By similarity).
REGION 364 365 IMP binding (By similarity).
REGION 388 392 IMP binding (By similarity).
ACT_SITE 308 308 Thioimidate intermediate (By similarity).
METAL 303 303 Potassium; via carbonyl oxygen (By
METAL 305 305 Potassium; via carbonyl oxygen (By
METAL 308 308 Potassium; via carbonyl oxygen (By
METAL 476 476 Potassium; via carbonyl oxygen; shared
METAL 477 477 Potassium; via carbonyl oxygen; shared
METAL 478 478 Potassium; via carbonyl oxygen; shared
BINDING 250 250 NAD (By similarity).
BINDING 306 306 IMP (By similarity).
BINDING 422 422 IMP (By similarity). |
Keyword | CBS domain; Complete proteome; GMP biosynthesis; Metal-binding; NAD; Oxidoreductase; Potassium; Purine biosynthesis; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 493 AA |
Protein Sequence | MDEGKILYEG LTFDDVLLLP DYSEVLPKEV SVRTRLTKRL FLNIPILSAA MDTVTEAEMA 60
IAMAREGGLG VIHKNLSIEA QAAMVRKVKR SEAGMIQDPV TLPPTATLED AERLMREYRI 120
GGLPVVDVYG RLLGLVTNRD LRFERDLKRP VTEVMTPVER LVTARPGTTL EEAEELLRRH 180
KVEKLPLVDE SGRLKGLITL KDIVKRRQYP NAVKDAQGRL LVGAAVGASK DLPERAQALV 240
EAGVDVLVLD SAHGHSKGIL EALAYLKETF GERVEVIAGN VATREGARAL AERGADAVKV 300
GIGPGSICTT RVVTGVGVPQ ITAILEAVAG VKDLDVPVIA DGGIKYTGDV AKAIAAGAHA 360
VMLGSMLAGT DEAPGEEVLK DGRRYKLYRG MGSLGAMKQG SADRYFQDPE KGETEAKKLV 420
PEGIEGMVPY KGPVADVLYQ IVGGLRSAMG YVGAPDIETF RKKARFVRMT MAGLIESHPH 480
DVVVVKEAPN YSR 493 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |