CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028805
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 
Protein Synonyms/Alias
  
Gene Name
 Pde1a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
394SLSAVDLKSFKNNLVubiquitination[1]
408VDIIQQNKERWKELAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 420 AA 
Protein Sequence
MGMMKKKPEE KPKFRSIVHA VQAGIFVERM YRKNYHMVGL TYPAAVIVTL KEVDKWSFDV 60
FALNEASGEH SLKFMIYELF TRYDLINRFK IPVSCLIAFA EALEVGYSKH KNPYHNLVHA 120
ADVTQTVHYI MLHTGIMHWL TELEILAMVF AAAIHDYEHT GTTNNFHIQT RSDVAILYND 180
RSVLENHHVS AAYRLMQEEE MNILVNLSKD DWRDLRNLVI EMVLATDMSG HFQQIKNIRN 240
SLQQPEGIDR AKTMSLILHA ADISHPAKTW KLHYRWTMAL MEEFFLQGDK EAELGLPFSP 300
LCDRKSTMVA QSQIGFIDFI VEPTFSLLTD STEKIVIPLI EEASKSQSSN YGASSSSTMI 360
GFHVADSLRR SNTKGSVCDG SYAPDYSLSA VDLKSFKNNL VDIIQQNKER WKELAAQGCC 420 
Gene Ontology
 GO:0048101; F:calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; ISO:MGI.
 GO:0004117; F:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; ISO:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR003607; HD/PDEase_dom.
 IPR023088; PDEase.
 IPR002073; PDEase_catalytic_dom.
 IPR023174; PDEase_CS.
 IPR013706; PDEase_N. 
Pfam
 PF00233; PDEase_I
 PF08499; PDEase_I_N 
SMART
 SM00471; HDc 
PROSITE
 PS00126; PDEASE_I 
PRINTS
 PR00387; PDIESTERASE1.