Tag | Content |
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CPLM ID | CPLM-024431 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Xin actin-binding repeat-containing protein 2 |
Protein Synonyms/Alias | Beta-xin; Cardiomyopathy-associated protein 3; Xeplin |
Gene Name | XIRP2 |
Gene Synonyms/Alias | CMYA3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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1877 | RLSNSHHKSNVLESG | methylation | [1] | 1944 | NSIQSAGKTVGKQQT | methylation | [1] | 2799 | EPNKSGLKTFQTLLN | methylation | [1] |
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Reference | [1] Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome. Bremang M, Cuomo A, Agresta AM, Stugiewicz M, Spadotto V, Bonaldi T. Mol Biosyst. 2013 Jul 30;9(9):2231-47. [ PMID: 23748837] |
Functional Description | Protects actin filaments from depolymerization. |
Sequence Annotation | REPEAT 362 377 Xin 1. REPEAT 397 412 Xin 2. REPEAT 437 452 Xin 3. REPEAT 474 489 Xin 4. REPEAT 512 527 Xin 5. REPEAT 552 567 Xin 6. REPEAT 590 605 Xin 7. REPEAT 628 643 Xin 8. REPEAT 661 676 Xin 9. REPEAT 695 710 Xin 10. REPEAT 732 747 Xin 11. REPEAT 768 783 Xin 12. REPEAT 799 814 Xin 13. REPEAT 837 852 Xin 14. REPEAT 875 890 Xin 15. REPEAT 914 929 Xin 16. REPEAT 947 962 Xin 17. REPEAT 985 1000 Xin 18. REPEAT 1020 1035 Xin 19. REPEAT 1059 1074 Xin 20. REPEAT 1095 1110 Xin 21. REPEAT 1132 1147 Xin 22. REPEAT 1170 1185 Xin 23. REPEAT 1207 1222 Xin 24. REPEAT 1241 1256 Xin 25. REPEAT 1272 1287 Xin 26. REPEAT 1310 1325 Xin 27. REPEAT 1345 1360 Xin 28. MOD_RES 1989 1989 Phosphothreonine (By similarity). MOD_RES 1994 1994 Phosphoserine (By similarity). |
Keyword | 3D-structure; Actin-binding; Alternative splicing; Cell junction; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 3374 AA |
Protein Sequence | MSPESGHSRI FEATAGPNKP ESGFAEDSAA RGEGVSDLHE VVSLKERMAR YQAAVSRGDC 60 RSFSANMMEE SEMCAVPGGL AKVKKQFEDE ITSSRNTFAQ YQYQHQNRSE QEAIHSSQVG 120 TSRSSQEMAR NEQEGSKVQK IDVHGTEMVS HLEKHTEEVN QASQFHQYVQ ETVIDTPEDE 180 EIPKVSTKLL KEQFEKSAQE KILYSDKEMT TPAKQIKTES EYEETFKPSS VVSTSSTSCV 240 STSQRKETST TRYSDHSVTS STLAQINATS SGMTEEFPPP PPDVLQTSVD VTAFSQSPEL 300 PSPPRRLPVP KDVYSKQRNL YELNRLYKHI HPELRKNLEK DYISEVSEIV SSQMNSGSSV 360 SADVQQARYV FENTNDSSQK DLNSEREYLE WDEILKGEVQ SIRWIFENQP LDSINNGSPD 420 EGDISRGIAD QEIIAGGDVK YTTWMFETQP IDTLGAYSSD TVENAEKIPE LARGDVCTAR 480 WMFETRPLDS MNKMHQSQEE SAVTISKDIT GGDVKTVRYM FETQHLDQLG QLHSVDEVHL 540 LQLRSELKEI KGNVKRSIKC FETQPLYVIR DGSGQMLEIK TVHREDVEKG DVRTARWMFE 600 TQPLDTINKD ITEIKVVRGI SMEENVKGGV SKAKWLFETQ PLEKIKESEE VIIEKEKIIG 660 TDVSRKCWMF ETQPLDILKE VPDADSLQRE EIIGGDVQTT KHLFETLPIE ALKDSPDIGK 720 LQKITASEEE KGDVRHQKWI FETQPLEDIR KDKKEYTRTV KLEEVDRGDV KNYTHIFESN 780 NLIKFDASHK IEVEGVTRGA VELNKSLFET TPLYAIQDPL GKYHQVKTVQ QEEIVRGDVR 840 SCRWLFETRP IDQFDESIHK FQIIRGISAQ EIQTGNVKSA KWLFETQPLD SIKYFSDVEE 900 TESKTEQTRD IVKGDVKTCK WLFETQPMES LYEKVSLMTS SEEIHKGDVK TCTWLFETQP 960 LDTIKDDSET AVKLQTVKQE EIQGGDVRTA CFLFETENLD SIQGEEVKEI KPVEMDIQAG 1020 DVSSMRYKFE NQSLDSISSS SEEVLKKIKT LKTEDIQKGN VLNCRWLFEN QPIDKIKESQ 1080 EGDECVKTVT DIQGGDVRKG CFIFETFSLD EIKEESDYIS TKKTITEEVI QGDVKSYRML 1140 FETQPLYAIQ DREGSYHEVT TVKKEEVIHG DVRGTRWLFE TKPLDSINKS ETVYVIKSVT 1200 QEDIQKGDVS SVRYRFETQP LDQISEESHN IMPSIDHIQG GNVKTSRQFF ESENFDKNNY 1260 IRTVSVNEIQ KGNVKTSTWL FETHTMDELR GEGLEYENIK TVTQEDVQKG DVKQAVWLFE 1320 NRTFDSIMEA HKGITKMTKE EIPPSDVKTT TWLFETTPLH EFNETRVEKI EIIGKSIKET 1380 LEDLYSQKVI QAPGIIIEAD EIGDVRMAKY KLMNQASPEI QKEEIIRADL RNIMVNLLSK 1440 RDCTEREILI SEEEKGNVNL TKTQLLNRST EFHAEKEEIV KGDVQQAIKN LFSEERSVKK 1500 GILIQEDEKG DINMTIYCLL HENDGDTIER EEVIGGDVKR TIHNLLSSTS NNKISERAKI 1560 DASERGNVQF FTTCIEAGAL DYLKQLHTES NETLTAKKQE GEKEIIGGDV EGTKLLLKKR 1620 QSLVERTVSE TDIIPGDVHN TVKVFMTEPQ STFGKIPKEE IIKGDLTSTL NSLSQAVNQK 1680 TVTKTEEIIK GNMLATLKSL KESSHRWKES KQPDAIPGDI EKAIECLEKA TNTKTEILKK 1740 ELLKDDLETS LRSLKEAQRS FKEVHKEGVI KKDAKAVMAG SSGEQKTDIH QVAVQRNKNS 1800 LLQPKPGPFE PAAKWQGGAD TLSQTMGKSC HGNLVEERTE VNLPKAPKGT VKIVIDREQN 1860 NDALEKSLRR LSNSHHKSNV LESGDKTGVW TDTTGEQHLR DEYMSRQLTS TVSVKNNLTT 1920 KESDRAVREL KKDDVFNSIQ SAGKTVGKQQ TYELRNDHQK MEGFHIKSPK KTKNIKILTD 1980 TQSSKPSPTQ HPVSMPVGGT YDLSGDFQKQ TLLKQETKYS NKDIKKKNIN LQPMWQLLPV 2040 EQDTSNVTEM KVSEKSHNTF KATNKKRETD VHLKSQDFLM KTNTSTGLKM AMERSLNPIN 2100 FNPENNVKES ECPLPPPSPP PPPPSNASSE IEFPLPPPPP LMMFPEKNGF LPSLSTEKIK 2160 AEFESFPGLP LPPPPVDEKS ERESSSMFLP PPPPPTPSQK PAHLLSSSAP EKHSGDFMQQ 2220 YSQKEASNSQ NSQAKIITGK TGVLPPPTLP KPKLPKHIKD NKNDFSPKVE LATSLSDMEC 2280 KITTSKDQKK VMVMTSSEHT ETKQNVISKS LDERKQLSID SANCLSHTVP GTSAPRKKQI 2340 APLIKSHSFP ESSGQQNPKP YMRKFKTPLM IAEEKYRQQK EEIEKQKQES SYYNIVKTQS 2400 QNQHITEVEK EMPLQKTNEE VSLSGIDSEC TVVQPSPGSQ SNARILGVCS DNQLSTTSPE 2460 TVAAKRLHHV LAASEDKDKM KKEVLQSSRD IMQSKSACEI KQSHQECSTQ QTQQKKYLEQ 2520 LHLPQSKPIS PNFKVKTIKL PTLDHTLNET DHSYESHKQQ SEIDVQTFTK KQYLKTKKTE 2580 ASTECSHKQS LAERHYQLPK KEKRVTVQLP TESIQKNQED KLKMVPRKQR EFSGSDRGKL 2640 PGSEEKNQGP SMIGRKEERL ITERKHEHLK NKSAPKVVKQ KVIDAHLDSQ TQNFQQTQIQ 2700 TAESKAEHKK LPQPYNSLQE EKCLEVKGIQ EKQVFSNTKD SKQEITQNKS FFSSVKESQR 2760 DDGKGALNIV EFLRKREELQ QILSRVKQFE AEPNKSGLKT FQTLLNTIPG WLISEDKREY 2820 AVHIAMENNL EKVKEEITHI KTQAEDMLVS YENIIQTAMM SSKTGKPGNK PTSLDETSSK 2880 VSNVHVSNNK NSEQKENKIA KEKTVQHQVA AHHEATVRSH VKTHQEIKLD DSNIPPPSLK 2940 TRPPSPTFIT IESTARRTEN PTKNELSQSP KKDSYVEPPP RRPMSQKSEI HRANTSPSPP 3000 RSRSEQLVRL KDTTAKLSKG AIPCPAATPV PIVEKRSEII MSPATLRRQI KIETRGRDSP 3060 PTITIPVNIN HAASGSFRES VDAQEEIRKV EKRATYVHKD GLNSTDHMVP DTESYDAVEI 3120 IRKVAVPPRL SEHTQRYEAA NRTVQMAENF VNDPENEINR WFREFEHGPV SEAKSNRRVY 3180 AKGETNHNIQ QESRTFCKEE FGLTSLGNTS FTDFSCKHPR ELREKIPVKQ PRICSETRSL 3240 SEHFSGMDAF ESQIVESKMK TSSSHSSEAG KSGCDFKHAP PTYEDVIAGH ILDISDSPKE 3300 VRKNFQKTWQ ESGRVFKGLG YATADASATE MRTTFQEESA FISEAAAPRQ GNMYTLSKDS 3360 LSNGVPSGRQ AEFS 3374 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-SubCell. GO:0030036; P:actin cytoskeleton organization; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |