CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024431
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Xin actin-binding repeat-containing protein 2 
Protein Synonyms/Alias
 Beta-xin; Cardiomyopathy-associated protein 3; Xeplin 
Gene Name
 XIRP2 
Gene Synonyms/Alias
 CMYA3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1877RLSNSHHKSNVLESGmethylation[1]
1944NSIQSAGKTVGKQQTmethylation[1]
2799EPNKSGLKTFQTLLNmethylation[1]
Reference
 [1] Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome.
 Bremang M, Cuomo A, Agresta AM, Stugiewicz M, Spadotto V, Bonaldi T.
 Mol Biosyst. 2013 Jul 30;9(9):2231-47. [PMID: 23748837
Functional Description
 Protects actin filaments from depolymerization. 
Sequence Annotation
 REPEAT 362 377 Xin 1.
 REPEAT 397 412 Xin 2.
 REPEAT 437 452 Xin 3.
 REPEAT 474 489 Xin 4.
 REPEAT 512 527 Xin 5.
 REPEAT 552 567 Xin 6.
 REPEAT 590 605 Xin 7.
 REPEAT 628 643 Xin 8.
 REPEAT 661 676 Xin 9.
 REPEAT 695 710 Xin 10.
 REPEAT 732 747 Xin 11.
 REPEAT 768 783 Xin 12.
 REPEAT 799 814 Xin 13.
 REPEAT 837 852 Xin 14.
 REPEAT 875 890 Xin 15.
 REPEAT 914 929 Xin 16.
 REPEAT 947 962 Xin 17.
 REPEAT 985 1000 Xin 18.
 REPEAT 1020 1035 Xin 19.
 REPEAT 1059 1074 Xin 20.
 REPEAT 1095 1110 Xin 21.
 REPEAT 1132 1147 Xin 22.
 REPEAT 1170 1185 Xin 23.
 REPEAT 1207 1222 Xin 24.
 REPEAT 1241 1256 Xin 25.
 REPEAT 1272 1287 Xin 26.
 REPEAT 1310 1325 Xin 27.
 REPEAT 1345 1360 Xin 28.
 MOD_RES 1989 1989 Phosphothreonine (By similarity).
 MOD_RES 1994 1994 Phosphoserine (By similarity).  
Keyword
 3D-structure; Actin-binding; Alternative splicing; Cell junction; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3374 AA 
Protein Sequence
MSPESGHSRI FEATAGPNKP ESGFAEDSAA RGEGVSDLHE VVSLKERMAR YQAAVSRGDC 60
RSFSANMMEE SEMCAVPGGL AKVKKQFEDE ITSSRNTFAQ YQYQHQNRSE QEAIHSSQVG 120
TSRSSQEMAR NEQEGSKVQK IDVHGTEMVS HLEKHTEEVN QASQFHQYVQ ETVIDTPEDE 180
EIPKVSTKLL KEQFEKSAQE KILYSDKEMT TPAKQIKTES EYEETFKPSS VVSTSSTSCV 240
STSQRKETST TRYSDHSVTS STLAQINATS SGMTEEFPPP PPDVLQTSVD VTAFSQSPEL 300
PSPPRRLPVP KDVYSKQRNL YELNRLYKHI HPELRKNLEK DYISEVSEIV SSQMNSGSSV 360
SADVQQARYV FENTNDSSQK DLNSEREYLE WDEILKGEVQ SIRWIFENQP LDSINNGSPD 420
EGDISRGIAD QEIIAGGDVK YTTWMFETQP IDTLGAYSSD TVENAEKIPE LARGDVCTAR 480
WMFETRPLDS MNKMHQSQEE SAVTISKDIT GGDVKTVRYM FETQHLDQLG QLHSVDEVHL 540
LQLRSELKEI KGNVKRSIKC FETQPLYVIR DGSGQMLEIK TVHREDVEKG DVRTARWMFE 600
TQPLDTINKD ITEIKVVRGI SMEENVKGGV SKAKWLFETQ PLEKIKESEE VIIEKEKIIG 660
TDVSRKCWMF ETQPLDILKE VPDADSLQRE EIIGGDVQTT KHLFETLPIE ALKDSPDIGK 720
LQKITASEEE KGDVRHQKWI FETQPLEDIR KDKKEYTRTV KLEEVDRGDV KNYTHIFESN 780
NLIKFDASHK IEVEGVTRGA VELNKSLFET TPLYAIQDPL GKYHQVKTVQ QEEIVRGDVR 840
SCRWLFETRP IDQFDESIHK FQIIRGISAQ EIQTGNVKSA KWLFETQPLD SIKYFSDVEE 900
TESKTEQTRD IVKGDVKTCK WLFETQPMES LYEKVSLMTS SEEIHKGDVK TCTWLFETQP 960
LDTIKDDSET AVKLQTVKQE EIQGGDVRTA CFLFETENLD SIQGEEVKEI KPVEMDIQAG 1020
DVSSMRYKFE NQSLDSISSS SEEVLKKIKT LKTEDIQKGN VLNCRWLFEN QPIDKIKESQ 1080
EGDECVKTVT DIQGGDVRKG CFIFETFSLD EIKEESDYIS TKKTITEEVI QGDVKSYRML 1140
FETQPLYAIQ DREGSYHEVT TVKKEEVIHG DVRGTRWLFE TKPLDSINKS ETVYVIKSVT 1200
QEDIQKGDVS SVRYRFETQP LDQISEESHN IMPSIDHIQG GNVKTSRQFF ESENFDKNNY 1260
IRTVSVNEIQ KGNVKTSTWL FETHTMDELR GEGLEYENIK TVTQEDVQKG DVKQAVWLFE 1320
NRTFDSIMEA HKGITKMTKE EIPPSDVKTT TWLFETTPLH EFNETRVEKI EIIGKSIKET 1380
LEDLYSQKVI QAPGIIIEAD EIGDVRMAKY KLMNQASPEI QKEEIIRADL RNIMVNLLSK 1440
RDCTEREILI SEEEKGNVNL TKTQLLNRST EFHAEKEEIV KGDVQQAIKN LFSEERSVKK 1500
GILIQEDEKG DINMTIYCLL HENDGDTIER EEVIGGDVKR TIHNLLSSTS NNKISERAKI 1560
DASERGNVQF FTTCIEAGAL DYLKQLHTES NETLTAKKQE GEKEIIGGDV EGTKLLLKKR 1620
QSLVERTVSE TDIIPGDVHN TVKVFMTEPQ STFGKIPKEE IIKGDLTSTL NSLSQAVNQK 1680
TVTKTEEIIK GNMLATLKSL KESSHRWKES KQPDAIPGDI EKAIECLEKA TNTKTEILKK 1740
ELLKDDLETS LRSLKEAQRS FKEVHKEGVI KKDAKAVMAG SSGEQKTDIH QVAVQRNKNS 1800
LLQPKPGPFE PAAKWQGGAD TLSQTMGKSC HGNLVEERTE VNLPKAPKGT VKIVIDREQN 1860
NDALEKSLRR LSNSHHKSNV LESGDKTGVW TDTTGEQHLR DEYMSRQLTS TVSVKNNLTT 1920
KESDRAVREL KKDDVFNSIQ SAGKTVGKQQ TYELRNDHQK MEGFHIKSPK KTKNIKILTD 1980
TQSSKPSPTQ HPVSMPVGGT YDLSGDFQKQ TLLKQETKYS NKDIKKKNIN LQPMWQLLPV 2040
EQDTSNVTEM KVSEKSHNTF KATNKKRETD VHLKSQDFLM KTNTSTGLKM AMERSLNPIN 2100
FNPENNVKES ECPLPPPSPP PPPPSNASSE IEFPLPPPPP LMMFPEKNGF LPSLSTEKIK 2160
AEFESFPGLP LPPPPVDEKS ERESSSMFLP PPPPPTPSQK PAHLLSSSAP EKHSGDFMQQ 2220
YSQKEASNSQ NSQAKIITGK TGVLPPPTLP KPKLPKHIKD NKNDFSPKVE LATSLSDMEC 2280
KITTSKDQKK VMVMTSSEHT ETKQNVISKS LDERKQLSID SANCLSHTVP GTSAPRKKQI 2340
APLIKSHSFP ESSGQQNPKP YMRKFKTPLM IAEEKYRQQK EEIEKQKQES SYYNIVKTQS 2400
QNQHITEVEK EMPLQKTNEE VSLSGIDSEC TVVQPSPGSQ SNARILGVCS DNQLSTTSPE 2460
TVAAKRLHHV LAASEDKDKM KKEVLQSSRD IMQSKSACEI KQSHQECSTQ QTQQKKYLEQ 2520
LHLPQSKPIS PNFKVKTIKL PTLDHTLNET DHSYESHKQQ SEIDVQTFTK KQYLKTKKTE 2580
ASTECSHKQS LAERHYQLPK KEKRVTVQLP TESIQKNQED KLKMVPRKQR EFSGSDRGKL 2640
PGSEEKNQGP SMIGRKEERL ITERKHEHLK NKSAPKVVKQ KVIDAHLDSQ TQNFQQTQIQ 2700
TAESKAEHKK LPQPYNSLQE EKCLEVKGIQ EKQVFSNTKD SKQEITQNKS FFSSVKESQR 2760
DDGKGALNIV EFLRKREELQ QILSRVKQFE AEPNKSGLKT FQTLLNTIPG WLISEDKREY 2820
AVHIAMENNL EKVKEEITHI KTQAEDMLVS YENIIQTAMM SSKTGKPGNK PTSLDETSSK 2880
VSNVHVSNNK NSEQKENKIA KEKTVQHQVA AHHEATVRSH VKTHQEIKLD DSNIPPPSLK 2940
TRPPSPTFIT IESTARRTEN PTKNELSQSP KKDSYVEPPP RRPMSQKSEI HRANTSPSPP 3000
RSRSEQLVRL KDTTAKLSKG AIPCPAATPV PIVEKRSEII MSPATLRRQI KIETRGRDSP 3060
PTITIPVNIN HAASGSFRES VDAQEEIRKV EKRATYVHKD GLNSTDHMVP DTESYDAVEI 3120
IRKVAVPPRL SEHTQRYEAA NRTVQMAENF VNDPENEINR WFREFEHGPV SEAKSNRRVY 3180
AKGETNHNIQ QESRTFCKEE FGLTSLGNTS FTDFSCKHPR ELREKIPVKQ PRICSETRSL 3240
SEHFSGMDAF ESQIVESKMK TSSSHSSEAG KSGCDFKHAP PTYEDVIAGH ILDISDSPKE 3300
VRKNFQKTWQ ESGRVFKGLG YATADASATE MRTTFQEESA FISEAAAPRQ GNMYTLSKDS 3360
LSNGVPSGRQ AEFS 3374 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro. 
Interpro
 IPR012510; Actin-binding_Xin_repeat. 
Pfam
 PF08043; Xin 
SMART
  
PROSITE
 PS51389; XIN 
PRINTS