UniProt Accession

 Q95VT2_TOXGO; Q95VT2; B6KPG7; B9PXY0; B9QKN7; Q1JSE9 

Genbank Protein ID

 AF406555; AM055943; DS984740; EQ967488; EQ970693 

Genbank Nucleotide ID

 AAL01371.1; CAJ20676.1; EEB02600.1; EEE21287.1; EEE28956.1 

Protein Name

 Histone H2B 

Protein Synonyms/Alias

  

Gene Name

 TGGT1_022960, TgIb.2030, TGME49_009910, TGVEG_038620 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Toxoplasma gondii 

NCBI Taxa ID

 5811 

Lysine Modification

Position	Peptide	Type	References
4	****MSGKGPAQKSQ	acetylation	[1]
9	SGKGPAQKSQAAKKT	acetylation	[1, 2]
14	AQKSQAAKKTAGKSL	acetylation	[1, 2]
15	QKSQAAKKTAGKSLG	acetylation	[1, 2]
19	AAKKTAGKSLGPRYR	acetylation	[1, 2]
113	HAVSEGTKAVTKYTT	acetylation	[1]
117	EGTKAVTKYTTSGA*	acetylation	[1]

Reference

 [1] Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii.
 Xue B, Jeffers V, Sullivan WJ, Uversky VN.
 Mol Biosyst. 2013 Apr 5;9(4):645-57. [PMID: 23403842]
 [2] Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.
 Jeffers V, Sullivan WJ Jr.
 Eukaryot Cell. 2012 Jun;11(6):735-42. [PMID: 22544907] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). 

Sequence Annotation

  

Keyword

 Chromosome; Complete proteome; DNA-binding; Isopeptide bond; Nucleosome core; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 123 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000558; Histone_H2B. 

Pfam

 PF00125; Histone 

SMART

 SM00427; H2B 

PROSITE

 PS00357; HISTONE_H2B 

PRINTS

 PR00621; HISTONEH2B.