UniProt Accession

 LAT2_HUMAN; Q9UHI5; B2R8Q4; B4DKT4; B4DTV6; D3DS46; F2Z2J4; Q86U05; Q9UKQ6; Q9UKQ7; Q9UKQ8; Q9Y445 

Genbank Protein ID

 AF135828; AF135829; AF135830; AF171669; Y18483; AB037669; BX248288; AK296702; AK300384; AK313465; AL117258; CH471078; CH471078; BC052250 

Genbank Nucleotide ID

 AAF05695.1; AAF05696.1; AAF05697.1; AAF20381.1; CAB40137.1; BAB21519.1; CAD62616.1; BAG59296.1; BAG62118.1; BAG36251.1; EAW66181.1; EAW66182.1; AAH52250.1 

Protein Name

 Large neutral amino acids transporter small subunit 2 

Protein Synonyms/Alias

 L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 

Gene Name

 SLC7A8 

Gene Synonyms/Alias

 LAT2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
525	MYQPTPTKDKDVAGQ	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. 

Sequence Annotation

  

Keyword

 Alternative splicing; Amino-acid transport; Cell membrane; Complete proteome; Cytoplasm; Disulfide bond; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 535 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0015179; F:L-amino acid transmembrane transporter activity; IEA:Compara.
 GO:0015175; F:neutral amino acid transmembrane transporter activity; TAS:ProtInc.
 GO:0015101; F:organic cation transmembrane transporter activity; IDA:UniProtKB.
 GO:0042605; F:peptide antigen binding; ISS:UniProtKB.
 GO:0019534; F:toxin transporter activity; IDA:UniProtKB.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0006520; P:cellular amino acid metabolic process; TAS:ProtInc.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0055065; P:metal ion homeostasis; NAS:UniProtKB.
 GO:0009636; P:response to toxic substance; NAS:UniProtKB. 

Interpro

 IPR002293; AA/rel_permease1.
 IPR004760; L_AA_transporter. 

Pfam

  

SMART

  

PROSITE

  

PRINTS