| Tag | Content |
|---|
| CPLM ID | CPLM-021796 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Profilin-2 |
Protein Synonyms/Alias | Profilin II |
Gene Name | Pfn2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 91 | CTMDIRTKSQGGEPT | ubiquitination | [1] | | 133 | KKAYSMAKYLRDSGF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. |
Sequence Annotation | MOD_RES 99 99 Phosphotyrosine. |
Keyword | 3D-structure; Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 140 AA |
Protein Sequence | MAGWQSYVDN LMCDGCCQEA AIVGYCDAKY VWAATAGGVF QSITPVEIDM IVGKDREGFF 60
TNGLTLGAKK CSVIRDSLYV DGDCTMDIRT KSQGGEPTYN VAVGRAGRVL VFVMGKEGVH 120
GGGLNKKAYS MAKYLRDSGF 140 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0043195; C:terminal bouton; IDA:MGI. GO:0030036; P:actin cytoskeleton organization; IEA:InterPro. GO:0030837; P:negative regulation of actin filament polymerization; IDA:MGI. GO:0030838; P:positive regulation of actin filament polymerization; IMP:MGI. GO:2000300; P:regulation of synaptic vesicle exocytosis; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |