CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012384
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform 
Protein Synonyms/Alias
 PP2A B subunit isoform B'-delta; PP2A B subunit isoform B56-delta; PP2A B subunit isoform PR61-delta; PP2A B subunit isoform R5-delta 
Gene Name
 PPP2R5D 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
200DFQPNIAKKYIDQKFubiquitination[1]
335PVIVGLLKFWPKTHSubiquitination[1]
516AEDIQLLKRTVETEAubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. 
Sequence Annotation
 REPEAT 37 38 1.
 REPEAT 39 40 2.
 REPEAT 41 42 3.
 REPEAT 43 44 4.
 REPEAT 45 46 5.
 REPEAT 47 48 6; approximate.
 REPEAT 49 50 7; approximate.
 REPEAT 51 52 8.
 REGION 37 52 8 X 2 AA approximate tandem repeats of Q-
 MOTIF 523 530 SH3-binding; class I (Potential).
 MOTIF 548 565 Nuclear localization signal (Potential).
 MOD_RES 573 573 Phosphoserine.
 MOD_RES 598 598 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 602 AA 
Protein Sequence
MPYKLKKEKE PPKVAKCTAK PSSSGKDGGG ENTEEAQPQP QPQPQPQAQS QPPSSNKRPS 60
NSTPPPTQLS KIKYSGGPQI VKKELFIQKL RQCCVLFDFV SDPLSDLKFK EVKRAGLNEM 120
VEYITHSRDV VTEAIYPEAV TMFSVNLFRT LPPSSNPTGA EFDPEEDEPT LEAAWPHLQL 180
VYEFFLRFLE SPDFQPNIAK KYIDQKFVLA LLDLFDSEDP RERDFLKTIL HRIYGKFLGL 240
RAYIRRQINH IFYRFIYETE HHNGIAELLE ILGSIINGFA LPLKEEHKMF LIRVLLPLHK 300
VKSLSVYHPQ LAYCVVQFLE KESSLTEPVI VGLLKFWPKT HSPKEVMFLN ELEEILDVIE 360
PSEFSKVMEP LFRQLAKCVS SPHFQVAERA LYYWNNEYIM SLISDNAARV LPIMFPALYR 420
NSKSHWNKTI HGLIYNALKL FMEMNQKLFD DCTQQYKAEK QKGRFRMKER EEMWQKIEEL 480
ARLNPQYPMF RAPPPLPPVY SMETETPTAE DIQLLKRTVE TEAVQMLKDI KKEKVLLRRK 540
SELPQDVYTI KALEAHKRAE EFLTASQEAL 570 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0000159; C:protein phosphatase type 2A complex; IEA:InterPro.
 GO:0008601; F:protein phosphatase type 2A regulator activity; TAS:ProtInc.
 GO:0004722; F:protein serine/threonine phosphatase activity; TAS:Reactome.
 GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
 GO:0006096; P:glycolysis; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.
 GO:0007399; P:nervous system development; TAS:ProtInc.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.
 GO:0034166; P:toll-like receptor 10 signaling pathway; TAS:Reactome.
 GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
 GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.
 GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
 GO:0034146; P:toll-like receptor 5 signaling pathway; TAS:Reactome.
 GO:0034162; P:toll-like receptor 9 signaling pathway; TAS:Reactome.
 GO:0038123; P:toll-like receptor TLR1:TLR2 signaling pathway; TAS:Reactome.
 GO:0038124; P:toll-like receptor TLR6:TLR2 signaling pathway; TAS:Reactome.
 GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome. 
Interpro
 IPR016024; ARM-type_fold.
 IPR002554; PP2A_B56. 
Pfam
 PF01603; B56 
SMART
  
PROSITE
  
PRINTS