CPLM-007832

Genbank Nucleotide ID

60S ribosomal protein L21

Protein Synonyms/Alias

Homo sapiens (Human)

Position	Peptide	Type	References
21	MFSRPFRKHGVVPLA	ubiquitination	[1, 2, 3, 4]
35	ATYMRIYKKGDIVDI	ubiquitination	[3]
36	TYMRIYKKGDIVDIK	ubiquitination	[3]
43	KGDIVDIKGMGTVQK	ubiquitination	[1, 2, 3, 4, 5]
50	KGMGTVQKGMPHKCY	ubiquitination	[3]
78	AVGIVVNKQVKGKIL	ubiquitination	[1, 3, 4, 5, 6]
107	KSRDSFLKRVKENDQ	ubiquitination	[3]
122	KKKEAKEKGTWVQLK	ubiquitination	[3]
129	KGTWVQLKRQPAPPR	ubiquitination	[1, 3, 4, 5, 7]
146	HFVRTNGKEPELLEP	ubiquitination	[5, 6, 7, 8]

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
[5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
[6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[7] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
[8] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]

Functional Description

3D-structure; Complete proteome; Direct protein sequencing; Disease mutation; Hypotrichosis; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
GO:0003723; F:RNA binding; TAS:ProtInc.
GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
GO:0006414; P:translational elongation; TAS:Reactome.
GO:0006413; P:translational initiation; TAS:Reactome.
GO:0006415; P:translational termination; TAS:Reactome.
GO:0019083; P:viral transcription; TAS:Reactome.

IPR001147; Ribosomal_L21e.
IPR018259; Ribosomal_L21e_CS.
IPR008991; Translation_prot_SH3-like.

PF01157; Ribosomal_L21e

PS01171; RIBOSOMAL_L21E