UniProt Accession

 FBXW5_MOUSE; Q9QXW2; A2AJ36; A2AJ37; E9QMP0; Q3U368 

Genbank Protein ID

 AF176520; AK019715; AK154911; AL732557; AL732557; CH466542; BC010776 

Genbank Nucleotide ID

 AAF09130.1; BAB31841.1; BAE32921.1; CAM25629.1; CAM25630.1; EDL08255.1; AAH10776.1 

Protein Name

 F-box/WD repeat-containing protein 5 

Protein Synonyms/Alias

 F-box and WD-40 domain-containing protein 5 

Gene Name

 Fbxw5 

Gene Synonyms/Alias

 Fbw5 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
295	NVVKRLFKIQNLNAS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication (By similarity). The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. 

Sequence Annotation

 DOMAIN 3 49 F-box.
 REPEAT 90 129 WD 1.
 REPEAT 470 509 WD 2.
 REPEAT 511 551 WD 3.
 MOTIF 308 316 D-box.
 MOD_RES 151 151 Phosphoserine; by PLK4 (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation; Ubl conjugation pathway; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 573 AA 

Protein Sequence

Gene Ontology

 GO:0080008; C:Cul4-RING ubiquitin ligase complex; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB.
 GO:0051298; P:centrosome duplication; ISS:UniProtKB.
 GO:0007067; P:mitosis; IDA:UniProtKB.
 GO:0016567; P:protein ubiquitination; IDA:UniProtKB.
 GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB. 

Interpro

 IPR001810; F-box_dom_cyclin-like.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00646; F-box
 PF00400; WD40 

SMART

 SM00256; FBOX
 SM00320; WD40 

PROSITE

 PS50181; FBOX
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS