| Tag | Content |
|---|
| CPLM ID | CPLM-011643 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Target of rapamycin complex 1 subunit TCO89 |
Protein Synonyms/Alias | TORC1 subunit TCO89; 89 kDa TOR complex 1 protein |
Gene Name | TCO89 |
Gene Synonyms/Alias | YPL180W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 279 | EGQSKVTKEADIDDL | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. |
Sequence Annotation | MOD_RES 52 52 Phosphothreonine.
MOD_RES 82 82 Phosphothreonine.
MOD_RES 84 84 Phosphoserine.
MOD_RES 107 107 Phosphoserine.
MOD_RES 115 115 Phosphoserine.
MOD_RES 144 144 Phosphoserine.
MOD_RES 203 203 Phosphoserine.
MOD_RES 215 215 Phosphoserine.
MOD_RES 290 290 Phosphoserine.
MOD_RES 397 397 Phosphoserine.
MOD_RES 575 575 Phosphoserine.
MOD_RES 707 707 Phosphoserine. |
Keyword | Cell membrane; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Vacuole. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 799 AA |
Protein Sequence | MVHRGRTLKS DTDVTSLNAS TVSHQSKPFR QFSTRSRAKS NASFKGLRRV LTHDGTLDND 60
YFNKHNVSQK CKSSDALFRK RTISGLNMTA LTRVKSNQGK RSASFHSPVH NTLLSPKNSS 120
HSNTGTAGFG LKPRRSKSTQ SVLSLRDAQE SKKSESTTDE EVECFSEDNI EDGKVNNDKV 180
IAEHVMPEEK KNVQQLNQNE LQSPDSIDEQ EEDKSGTDGK ENHRAVSLPL PHLSSNNYFG 240
ESSHSIEHQK DGETSPSSIE TKLNATSVIN EEGQSKVTKE ADIDDLSSHS QNLRASLVKA 300
GDNISEAPYD KEKKILDVGN TLAAHKSNQK PSHSDEQFDQ EDHIDAPRSN SSRKSDSSFM 360
SLRRQSSKQH KLLNEEEDLI KPDDISSAGT KDIEGHSLLE NYAPNMILSQ STGVERRFEN 420
SSSIQNSLGN EIHDSGEHMA SGDTFNELDD GKLRKSKKNG GRSQLGQNIP NSQSTFPTIA 480
NIGSKDNNVP QHNFSTSISS LTNNLRRAAP ESFHGSRMNN IFHKKGNQNL LLRSNDLNKN 540
SAAPASPLSN EHITSSTNSG SDANRQSNSG AKFNSFAQFL KSDGIDAESR TQRKLWLQRE 600
NSIMDLSSQN DGSDSIFMAG NIDAKREFER ISHEYSNVKR FYNPLDEALL RVQPIITGNA 660
NNIRKKSHND AQSIAHSSSD TDHKDEDDLL FTNYDKKFDD LYPHLASAKI QAVLSGIWKS 720
ESYLFNKDVN PINKNRTTST NHSVGHTASQ NARNLLRGPM GSSTTLHHQR VINSLQPTTR 780
AVNRRMENVG YMHTQPQQR 799 |
Gene Ontology | GO:0031234; C:extrinsic to internal side of plasma membrane; IDA:SGD. GO:0000306; C:extrinsic to vacuolar membrane; IDA:SGD. GO:0000329; C:fungal-type vacuole membrane; IDA:SGD. GO:0031931; C:TORC1 complex; IPI:SGD. GO:0031505; P:fungal-type cell wall organization; IMP:SGD. GO:0006071; P:glycerol metabolic process; IGI:SGD. GO:0001558; P:regulation of cell growth; IPI:SGD. GO:0009651; P:response to salt stress; IMP:SGD. GO:0031929; P:TOR signaling cascade; IC:SGD. |
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PROSITE | |
PRINTS | |