CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017696
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AT-rich interactive domain-containing protein 1B 
Protein Synonyms/Alias
 ARID domain-containing protein 1B; BRG1-associated factor 250b; BAF250B; BRG1-binding protein hELD/OSA1; Osa homolog 2; hOsa2; p250R 
Gene Name
 ARID1B 
Gene Synonyms/Alias
 BAF250B; DAN15; KIAA1235; OSA2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1830KFDKLPIKIVKKNNLubiquitination[1]
2150PPFSRQEKFYATLVRubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically. 
Sequence Annotation
 DOMAIN 1053 1144 ARID.
 MOTIF 419 423 LXXLL.
 MOTIF 2036 2040 LXXLL.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 516 516 Phosphoserine.
 MOD_RES 1555 1555 Phosphoserine.
 MOD_RES 1559 1559 Phosphoserine.
 MOD_RES 1715 1715 Phosphoserine.
 MOD_RES 1777 1777 N6-acetyllysine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Chromatin regulator; Complete proteome; DNA-binding; Mental retardation; Neurogenesis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Triplet repeat expansion. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2236 AA 
Protein Sequence
MAHNAGAAAA AGTHSAKSGG SEAALKEGGS AAALSSSSSS SAAAAAASSS SSSGPGSAME 60
TGLLPNHKLK TVGEAPAAPP HQQHHHHHHA HHHHHHAHHL HHHHALQQQL NQFQQQQQQQ 120
QQQQQQQQQQ QHPISNNNSL GGAGGGAPQP GPDMEQPQHG GAKDSAAGGQ ADPPGPPLLS 180
KPGDEDDAPP KMGEPAGGRY EHPGLGALGT QQPPVAVPGG GGGPAAVPEF NNYYGSAAPA 240
SGGPGGRAGP CFDQHGGQQS PGMGMMHSAS AAAAGAPGSM DPLQNSHEGY PNSQCNHYPG 300
YSRPGAGGGG GGGGGGGGGS GGGGGGGGAG AGGAGAGAVA AAAAAAAAAA GGGGGGGYGG 360
SSAGYGVLSS PRQQGGGMMM GPGGGGAASL SKAAAGSAAG GFQRFAGQNQ HPSGATPTLN 420
QLLTSPSPMM RSYGGSYPEY SSPSAPPPPP SQPQSQAAAA GAAAGGQQAA AGMGLGKDMG 480
AQYAAASPAW AAAQQRSHPA MSPGTPGPTM GRSQGSPMDP MVMKRPQLYG MGSNPHSQPQ 540
QSSPYPGGSY GPPGPQRYPI GIQGRTPGAM AGMQYPQQQM PPQYGQQGVS GYCQQGQQPY 600
YSQQPQPPHL PPQAQYLPSQ SQQRYQPQQD MSQEGYGTRS QPPLAPGKPN HEDLNLIQQE 660
RPSSLPDLSG SIDDLPTGTE ATLSSAVSAS GSTSSQGDQS NPAQSPFSPH ASPHLSSIPG 720
GPSPSPVGSP VGSNQSRSGP ISPASIPGSQ MPPQPPGSQS ESSSHPALSQ SPMPQERGFM 780
AGTQRNPQMA QYGPQQTGPS MSPHPSPGGQ MHAGISSFQQ SNSSGTYGPQ MSQYGPQGNY 840
SRPPAYSGVP SASYSGPGPG MGISANNQMH GQGPSQPCGA VPLGRMPSAG MQNRPFPGNM 900
SSMTPSSPGM SQQGGPGMGP PMPTVNRKAQ EAAAAVMQAA ANSAQSRQGS FPGMNQSGLM 960
ASSSPYSQPM NNSSSLMNTQ APPYSMAPAM VNSSAASVGL ADMMSPGESK LPLPLKADGK 1020
EEGTPQPESK SKDSYSSQGI SQPPTPGNLP VPSPMSPSSA SISSFHGDES DSISSPGWPK 1080
TPSSPKSSSS TTTGEKITKV YELGNEPERK LWVDRYLTFM EERGSPVSSL PAVGKKPLDL 1140
FRLYVCVKEI GGLAQVNKNK KWRELATNLN VGTSSSAASS LKKQYIQYLF AFECKIERGE 1200
EPPPEVFSTG DTKKQPKLQP PSPANSGSLQ GPQTPQSTGS NSMAEVPGDL KPPTPASTPH 1260
GQMTPMQGGR SSTISVHDPF SDVSDSSFPK RNSMTPNAPY QQGMSMPDVM GRMPYEPNKD 1320
PFGGMRKVPG SSEPFMTQGQ MPNSSMQDMY NQSPSGAMSN LGMGQRQQFP YGASYDRRHE 1380
PYGQQYPGQG PPSGQPPYGG HQPGLYPQQP NYKRHMDGMY GPPAKRHEGD MYNMQYSSQQ 1440
QEMYNQYGGS YSGPDRRPIQ GQYPYPYSRE RMQGPGQIQT HGIPPQMMGG PLQSSSSEGP 1500
QQNMWAARND MPYPYQNRQG PGGPTQAPPY PGMNRTDDMM VPDQRINHES QWPSHVSQRQ 1560
PYMSSSASMQ PITRPPQPSY QTPPSLPNHI SRAPSPASFQ RSLENRMSPS KSPFLPSMKM 1620
QKVMPTVPTS QVTGPPPQPP PIRREITFPP GSVEASQPVL KQRRKITSKD IVTPEAWRVM 1680
MSLKSGLLAE STWALDTINI LLYDDSTVAT FNLSQLSGFL ELLVEYFRKC LIDIFGILME 1740
YEVGDPSQKA LDHNAARKDD SQSLADDSGK EEEDAECIDD DEEDEEDEEE DSEKTESDEK 1800
SSIALTAPDA AADPKEKPKQ ASKFDKLPIK IVKKNNLFVV DRSDKLGRVQ EFNSGLLHWQ 1860
LGGGDTTEHI QTHFESKMEI PPRRRPPPPL SSAGRKKEQE GKGDSEEQQE KSIIATIDDV 1920
LSARPGALPE DANPGPQTES SKFPFGIQQA KSHRNIKLLE DEPRSRDETP LCTIAHWQDS 1980
LAKRCICVSN IVRSLSFVPG NDAEMSKHPG LVLILGKLIL LHHEHPERKR APQTYEKEED 2040
EDKGVACSKD EWWWDCLEVL RDNTLVTLAN ISGQLDLSAY TESICLPILD GLLHWMVCPS 2100
AEAQDPFPTV GPNSVLSPQR LVLETLCKLS IQDNNVDLIL ATPPFSRQEK FYATLVRYVG 2160
DRKNPVCREM SMALLSNLAQ GDALAARAIA VQKGSIGNLI SFLEDGVTMA QYQQSQHNLM 2220
HMQPPPLEPP SVDMMCRAAK ALLAMARVDE NRSEFLLHEG RLLDISISAV LNSLVASVIC 2280
DVLFQIGQL 2289 
Gene Ontology
 GO:0016514; C:SWI/SNF complex; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IDA:GDB.
 GO:0003713; F:transcription coactivator activity; NAS:UniProtKB.
 GO:0048096; P:chromatin-mediated maintenance of transcription; NAS:UniProtKB.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001606; ARID/BRIGHT_DNA-bd.
 IPR011989; ARM-like.
 IPR021906; DUF3518. 
Pfam
 PF01388; ARID
 PF12031; DUF3518 
SMART
 SM00501; BRIGHT 
PROSITE
 PS51011; ARID 
PRINTS