CPLM-010641

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-010641

UniProt Accession

ANXA4_MOUSE; P97429; Q3UCL0

Genbank Protein ID

U72941; AK132293; AK150486; AK150614; AK151054; AK151236; AK167338; AK168390; AK168487; AK168917; AK170447; CH466523

Genbank Nucleotide ID

AAB40697.1; BAE21085.1; BAE29602.1; BAE29705.1; BAE30071.1; BAE30228.1; BAE39439.1; BAE40316.1; BAE40374.1; BAE40730.1; BAE41805.1; EDK99195.1

Protein Name

Annexin A4

Protein Synonyms/Alias

Annexin IV; Annexin-4

Gene Name

Anxa4

Gene Synonyms/Alias

Anx4

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
28	QTLRKAMKGLGTDED	ubiquitination	[1]
100	QELRRAMKGAGTDEG	ubiquitination	[1]
184	ELYEAGEKRWGTDEV	ubiquitination	[1]
246	IVKCMRSKPSYFAER	ubiquitination	[1]
259	ERLYKSMKGLGTDDN	ubiquitination	[1]
300	KSLYSFIKGDTSGDY	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis (By similarity).

Sequence Annotation

REPEAT 23 83 Annexin 1.
REPEAT 95 155 Annexin 2.
REPEAT 179 239 Annexin 3.
REPEAT 254 314 Annexin 4.
MOD_RES 7 7 Phosphothreonine (By similarity).
MOD_RES 213 213 N6-acetyllysine (By similarity).
MOD_RES 293 293 N6-acetyllysine (By similarity).
MOD_RES 300 300 N6-acetyllysine (By similarity).

Keyword

Acetylation; Annexin; Calcium; Calcium/phospholipid-binding; Complete proteome; Phosphoprotein; Reference proteome; Repeat.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

319 AA

Protein Sequence

MEAKGGTVKA ASGFNATEDA QTLRKAMKGL GTDEDAIIGI LAYRNTAQRQ EIRSAYKSTI 60
GRDLIEDLKS ELSSNFEQVI LGLMTPTVLY DVQELRRAMK GAGTDEGCLI EILASRTPEE 120
IRRINQTYQQ QYGRSLEEDI CSDTSFMFQR VLVSLSAAGR DEGNYLDDAL MKQDAQELYE 180
AGEKRWGTDE VKFLSILCSR NRNHLLHVFD EYKRISQKDI EQSIKSETSG SFEDALLAIV 240
KCMRSKPSYF AERLYKSMKG LGTDDNTLIR VMVSRAEIDM LDIRASFKRL YGKSLYSFIK 300
GDTSGDYRKV LLVLCGGDD 319

Gene Ontology

GO:0016324; C:apical plasma membrane; ISA:MGI.
GO:0005509; F:calcium ion binding; IEA:InterPro.
GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
GO:0001822; P:kidney development; ISA:MGI.

Interpro

IPR001464; Annexin.
IPR018502; Annexin_repeat.
IPR018252; Annexin_repeat_CS.
IPR002391; AnnexinIV.

Pfam

PF00191; Annexin

SMART

SM00335; ANX

PROSITE

PS00223; ANNEXIN

PRINTS

PR00196; ANNEXIN.